| Object:By analyzed40cases of IgG4-related sclerosing sialadenitiscorresponding to pathological diagnosis（benign lymphoepithelial lesion and chronicsclerosing sialadenitis）, aiming at discuss diagnosis and treatment of IgG4-relatedsclerosing sialadenitis, and explore more optimized treatment.Method:40cases diagnosed with benign lymphoepithelial lesion and chronicsclerosing sialadenitis were collected in the January2005to March2015at FirstHospital of Jilin University and Jilin university stomatological hospital. everypatient’s main symptom, associated symptoms (with calculus, history of infection),physical examination, the results of laboratory examinations, serology, pathologyresults of biopsy or surgery, operative and postoperative complications and follow-upand so on.Results:There were37cases with benign lymphepithelial lesions,3cases withChronic sclerosis Chronic sclerosis. There have13men and27women. The meanage and duration was fifty-three years old and one years. Longest duration is about5years, the shortest duration is10days. Fine needle aspiration in12cases,22cases ofsurgical resection.9cases with immunohistochemistry staining suggested non-clonalneoplastic. six cases showed prompt penetrate tissue is too small to diagnose, itsuggested removal of lesions completely.18cases occurred in submandibular gland,17cases occurred in parotid gland,2cases occurred in submandibular gland andparotid gland，2cases occurred in lymph nodes, and1case occurred in tongue. Mainauxiliary examination methods were ultrasound or CT examination,37cases do theultrasound examination, and3cases do CT examination.3cases of serum IgG4concentrations detected were significantly higher than normal.Conclusion: Patients had longer duration of average, and no history ofautoimmune disease. Pathological diagnosis relies on immunohistochemical stainingby detection of IgG4and IgG. Surgery is not the way to cure this disease, we should improve the accuracy of fine needle biopsy diagnosis.. |
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