Analysis Of Clinical Characteristics And Risk Factors Of Nonalcoholic Fatty Liver Disease With Chronic Hepatitis B

AIMS:With the change of the modern life style, diet and the improvementof living standards, the incidence of NAFLD is a trend of rising year byyear. NAFLD can promote the further development of CHB, the purposeof this article is to investigate the CHB merger basic clinicalcharacteristics and risk factors of NAFLD, to promote the CHB diseaseprogression, treatment and prognosis of help.METHOD:By the method of retrospective analysis of investigation in January2013-January2015clinic Yu Zhongri fellowship between hospital306cases of digestive internal medicine diagnosis of CHB patients, the siftingeligible patients were divided into pure CHB and merger of CHBNAFLD group, two groups of163cases and57cases respectively,analyze and compare the clinical characteristics and related risk factors.In57cases and163cases of eligible patients respectively in15cases ofpatients with liver tissue pathology, characteristics of two groups ofpatients with hepatic tissue pathology analysis. Beck man full automaticbiochemical analyzer test serum biochemical indexes. Clinical data andlaboratory index is derived from the clinic date for the first time.SPSSl7.0statistical software was used to statistical analysis, measurement data using percentile inspection, count data applicationchi-square test and rank and inspection were analyzed. Single factoranalysis using sequential inspection, multi-factor analysis by using theCox proportional hazards model, finally only single factor weresignificant variables into the Cox model analysis, the P <0.05forstatistical significance.RESULT:Merger in306patients with CHB patients with NAFLD57cases,accounts for about18.6%of the total. And CHB with the change trend ofthe number of patients with NAFLD is a trend of rising year by year. Inthe57cases of patients,40patients with male accounted for70.1%of thetotal,17cases accounted for29.8%of the total number of female patients,men and women than about2:1. In the male patients with high bloodpressure than the proportion of the number of women is low, P <0.05,with statistical significance. Merged group Child-pugh, classification isclass B more, only A few for class A and class C, and the control groupthe Child-pugh, classification for class A and class B, A handful of Acategory C, there is significant difference, P <0.05, with statisticalsignificance.15patients with CHB with NAFLD and simple the livertissue pathology feature comparison of patients with CHB liver tissuefibrosis degree has no obvious difference.Obesity in35patients withCHB with NAFLD accounted for61.0%of the total (BMI acuity25.0 kg/m2), the number of diabetes was31cases accounted for55.0%of thetotal, dyslipidemia and hypertension in all19cases,10cases, accountingfor33.3%33.3%of the total, respectively. Male patients HDL-C medianvalue was lower than those of women HDL-C median value, there aredifferences between, P <0.05, with statistical significance. Merger ofNAFLD patients with CHB group with pure CHB patients in the numberof blood lipids, BMI, diabetes, and there were significant differences (P <0.05, with statistical significance. Obesity, diabetes and dyslipidemia is amajor risk factor for patients with CHB with NAFLDCONCLUSION:Patients with CHB with NAFLD proportion occupies total numberin CHB is higher, and there is an upward trend in the proportion. Patientswith CHB with NAFLD male-dominated, male to female ratio is about2:1. Compared with pure CHB, the degree of liver fibrosis (P>0.05, nostatistical significance. But the child grading (P <0.05, there is statisticalsignificance, suggesting merger will accelerate CHB, progression tocirrhosis of the liver. Compared with the pure CHB patients with CHBpatients blood fat and BMI of NAFLD is larger, with the number ofdiabetes. Obesity, diabetes and hyperlipidemia are independent riskfactors promote the development of NAFLD for CHB...