Non-alcoholic Fatty Liver Disease Affects The Relationship Between Epicardium And Coronary Atherosclerotic Heart Disease

Objective:To explore the relationship between the various parts of the visceral fat (VF) andcoronary atherosclerotic heart disease (CAD), and to find whether Non-alcoholic fatty liverdisease (NAFLD) affects the correlation between VF and CAD. The results can provide a newreference index for the prevention, prediction, treatment and rehabilitation of CAD.Methods:This study selected339patients, they all underwent coronary angiography in the firsthospital of Jilin university.18patients who did not conform to the standard were excluded.196man and125women (61.69±7.31years old) were finally enrolled in this study. We usedultrasonography to measure the thickness of various parts VF and NAFLD. According to theresults of coronary angiography,we determined the patients with CAD and used Gensinivalue to evaluate the extent of lesion. Firstly, according to the results of coronary angiography,the patients were divided into CAD group and non CAD group to determine whether the VF,NAFLD are the independent risk factors of CAD. Secondly, according to Gensini value, thepatients were divided into three groups to investigate whether there is a relationship betweenVF and the severity of CAD. Finally, the enrolled patients were divided into NAFLD groupand non-NAFDL group to determine the relationship between NAFLD and VF, and theinfluence of NAFLD on the relationship between VF and CAD.Results:Using the statistics analysis, we found that epicardium, NAFLD, smoking, high bloodpressure, LDL-C, TG in CAD group were significantly higher than those in non-CAD group(P<0.05). HDL-C of CAD group was lower. There was no significant difference between thetwo groups in the thickness of perirenal fat, pararenal fat and liver fat (P>0.05). Logisticregression analysis revealed that smoking history, hypertention, epicardium had significant difference between the CAD group and the non-CAD group (P<0.05). The thickness of theepicardium and the sum of VF were increased gradually in the three groups of CAD, and therewere significant differences between the three groups (P<0.05). Compared with the nonNAFLD group, the thcikness of liver fat, perirenal fat, pararenal fat and epicardium inNAFLD group were significantly increased (P<0.05). In the NAFLD group and non NAFLDgroup, the thickness of the epicardium was associated with CAD, suggesting predictive valuefor the diagnosis of CAD. However, the cut-off value of CAD in NAFLD group was higherthan that of non NAFLD group. With the increase of Gensini value, the VF of NAFLD grouphad no significant increase (P>0.05). In non-NAFLD group,With the increase of Gensinivalue, the epicardium thickness in the three groups of CAD had a significant increase(P<0.05), and the thickness of other parts VF had no significant change (P>0.05).Conclusion:Epicardium, hypertension, smoking are independent risk factors of CAD. Epicardiumthickness is associated with the degree of coronary artery stenosis. The VF is easilyaccumulated in the patients with NAFLD. The epicardium thickness has a predictive value forthe incidence and the severity of CAD in patients without NAFLD. In patients with NAFLD,epicardium thickness has predictive value for the incidence of CAD, but there is no predictivevalue for the severity of CAD.