The Clinical Analysis Of57Cases Of Multi-organ Involvement In Patients With Systemic Sclerosis

Objective:By comparing57cases of multi-organ involvement in systemic sclerosis (SSc) patients’Renault phenomenon, laboratory examination and characteristic inspection to find out if they had differences and correlation, analysis of the law of the lesions, to provide a reference for clinical and further research.Methods:57patients who came to the first Hospital of JiLin University and diagnosed SSc were retrospectively analyzed of their clinical manifestations and established database. From the view of cardiovascular system, respiratory system, digestive system, urinary system, blood system and endocrine system, respectively compared with the control group to find differences between the clinical data of each system, and a retrospective analyzed of the patients’age, gender, Renault phenomenon, laboratory examination and characteristic inspection, using the method of statistical analysis of the corresponding conclusions. Results:1, Overall involvement:32cases of cardiovascular system,37cases of respiratory system,23cases of digestive system,21cases of urinary system,19cases of blood system,20cases of endocrine system.2, Renault phenomenon: cardiovascular system involvement and respiratory system involvement compared with its corresponding control group relatively had high incidence of Renault phenomenon, the difference were statistically significant (P<0.05).3, Laboratory examination:Cardiovascular system involvement compared with non cardiovascular system involvement had a high incidence of thyroid-stimulating hormone write, free T4left and blood sedimentation, the difference were statistically significant (P<0.05); Respiratory system involvement compared with non respiratory system involvement had a high incidence of the against Scl-70antibody positive, the difference was statistically significant (P<0.05); Digestive system involvement compared with non digestive system involvement had a high incidence of hemoglobin reduced, the difference was statistically significant (P<0.05); Urinary system involvement compared with non urinary system involvement had high incidence of hemoglobin reduced, albumin reduced, the difference were statistically significant (P<0.05); Blood system involvement compared with non blood system involvement had a high incidence of C3reduced, the difference was statistically significant (P<0.05); Endocrine system involvement compared with non endocrine system involvement had high incidence of myocardial enzyme rise, albumin reduced, the difference were statistically significant (P<0.05).4, Characteristic check:Electrocardiogram (ECG):31cases of normal,5cases of tachycardia,4cases of conduction block,13cases of primary T wave and ST-t change (22.8%),7cases of right ventricular hypertrophy; Echocardiography:26cases of normal. Ventricular hypertrophy8cases, mitral valve and/or tricuspid regurgitation10cases, diastolic function impairment7cases, decreased left ventricular ejection fraction9cases, pulmonary hypertension6cases, pericardial effusion15cases (26.3%). Myocardial enzyme:48cases of normal, Creatine kinase eleations8cases, elevated lactate dehydrogenase5cases, elevated creatine kinase isoenzyme6cases, alpha hydroxy butyric acid dehydrogenase increase4cases; Lung function:41cases of normal; diffuse lung function decline6cases, restrictive ventilatory dysfunction10cases; Lung row CT scan:4cases of normal; lung texture enhancement9cases, flake fuzzy of high density shade14cases, ground glass shadow27cases (47.4%), pulmonary artery6cases and pleural effusion7cases, pleural thickening3cases; Liver result:normal41cases, elevated ALT5cases, AST rise3cases, albumin fell13cases; Upper gastrointestinal angiography (barium):43cases of normal; lower esophagus mild expansion and peristalsis abate11cases, serious expansion and esophagus peristalsis disappear3cases; Routine urine:42cases of normal, ery positie6cases, urine protein positive5cases; Renal function:46cases of normal, urea nitrogen increased11cases, creatinine increased9cases; Blood routine:41cases of normal; white blood cells decline4cases, hemoglobin decline10cases, platelet decline8cases; Thyroid function three:35cases of normal; thyroid stimulating hormone rise22cases, free T3decline12cases, free T4decline20cases; Thyroid doppler colour:38cases of normal, thyroid density decreases13cases, thyroid nodule6cases.Conclusions:1, systemic sclerosis can cause multiple system damage, the respiratory system involvement happened most, cardiovascular system involvement take the second place;2, systemic sclerosis multi-system involvement have potential associated, cardiovascular involvement with endocrine involvement seems to be always exist at the same time;3, the respiratory system involvement had a high rate of against Scl-70antibody positive; Characterized by restrictive ventilatory dysfunction, flake fuzzy density shadow.