Correlation Study On32Cases In Children Endocardial Fibroelastosis Ventricular Remodeling And N-terminal Pro-B-type Natriuretic Peptide

Objective:To discuss children with endocardial fibroelastosis’s N-terminal pro-B-type natriuretic peptide variation tendency，and to analysis the relationshipbetween N-terminal pro-B-type natriuretic peptide and heart function,toanalysis the relativity between N-terminal pro-B-type natriuretic peptide andcardiac remodeling sign left ventricular mass index.Methods:Use the retrospective methods to analysis, Select32cases of children withEFE,who are in the first hospital of jilin university pediatric inpatient andoutpatient follow-up In January2011-January2015, randomly selected from thesame period pediatric medical healthy children.The first hospital of jilinuniversity,20cases, as healthy controls.Measured plasma NT-proBNP levelbefore and after treatment, apply improved RO-SS cardiac functionclassification rate to evaluate.Apply echocardiography to determine leftventricular ejection fraction (LVEF), short axial shortening rate (FS), diastolicventricular septal thickness (IVST), left ventricular end-diastolic ventriculardiameter (LVDD), left ventricular diastolic wall thickness (LVPWT), measurethe value of the endocardial thickness using the EXCEL software, SPSS21.0statistical software for statistical analysis.Consequence:(1) Heart failure group and healthy group two groups there was nostatistically significant difference in gender and age. Heart failure beforetreatment group compared with healthy controls, the plasma NT-proBNP difference had statistical significance (P<0.05); Comparing two heart failuregroup, the difference had statistical significance (P<0.05); LVEF, FS valuecomparison before treatment, comparing two heart failure group, the differencehad statistical significance (P<0.05); LVMI value comparison, comparing twoheart failure group, the difference had statistical significance (P<0.05);(2) With increasing levels of CHF, plasma NT-proBNP value increasedgradually, LVEF, FS gradually reduced, LVMI value increased gradually,gradually thickening of endocardial thickness. Children with EFE group plasmaNT-proBNP and negatively correlated with LVEF, FS (r=0.826,0.790, P <0.05). Plasma NT-proBNP and improved Ross heart failure classification werepositively correlated (r=0.963, P<0.05), LVEF, FS and improved Ross heartfailure classification were negatively correlated (r=0.765,0.652, P<0.05). Thecorrelation between the plasma NT-proBNP and heart failure classification withLVEF, FS is good. LVMI and improved Ross heart failure classification werepositively correlated (r=0.823, P<0.05). Children with EFE endocardialthickness and cardiac function classification has no relevance.The plasma NT-proBNP and left ventricular mass index (LVMI) were positively correlated (r=0.825, P<0.05).Conclusion:(1) NT-pro-BNP were increasing at the EFE children.(2) There Was the positive correlation between NT-pro-BNP/LVMI andheart function.(3) There Was the positive correlation between NT-pro-BNP and LVMI.(4) There Was the negative correlation between NT-pro-BNP and LVEF/FS.NT-pro-BNP is more susceptible than LVEF/FS in evaluate heart function.(5) NT-proBNP inspection of EFE cardiac function classification,assessment of curative effect, the degree of ventricular remodeling has theimportant clinical application value and guiding significance.