Prepare And Characterization Phosphazene-Contained Hard Tissue Restoration Materials

Oral hard tissues, including teeth and jaw, are an important organ of human body. They are closely related with our daily life. So when the oral hard tissues fill ill, the prompt treatment is necessary.Light-cured resin has been widely used in dental restorative materials. Bisphenol A glycidyl methacrylate (Bis-GMA) and triethylene glycol dimethacrylate (TEGDM) are the most common monomer of the light-cured composite resin. To avoid the gaps, which result in secondary caries, dental restorative resins normally require radiopacity, which is useful not only to evaluate restoration, but also to monitor its long-term stability. However, light-cured composite resin monomers are radiolucent, radiopacity is usually given by adding radiopacitying agents. Adding Heavy metals or heavy metal oxides is a commonly used method. But inorganic metal powders are incompatible with the organic resin matrix, and this will cause decrease of mechanical properties. So, inorganic radiopacity agent should be modified before used. In the other hand, introducing heavy metal elements may cause potential biocompatible problems. Another method to give the composite resin radiopacity is using the oganic agent which contains iodine element. These agents can overcome the problem of compatibility with the matrix, and give the composite resin an ideal radiopacity.Jaw defect, another oral hard tissue disease, often caused by odontopathy or external force injuries, was treated by autogenous bone graft in the past. However, the source of autogenous bone is limited, and this method will cause more pain to patients. Guided Tissue Regeneration can dissolve the source of bone, but Bio-OSS must be mixed with plasma and sealed by a guided tissue regeneration membrane to ensure long-term stability. In addition, Bio-OSS is not easy to mould and it cannot correspond to the shape of injured part. Injectable hydrogels are a kind of new hard tissue restorative materials. Hydrogels can not only be used with guided tissue regeneration technology to seal up Bio-OSS in wound, but also can be used in bone tissue engeneering.In this study, two materials based on phosphazene are synthesized for oral hard tissue restoration.4-iodoaniline-co-hydroxyethyl methylacrylate substituted cyclotriphosphazenes was synthesized as X-ray opaque monomer to instead of heavy metal powder to absorb X-ray in the composite resins without decreasing the mechanical properties of resins, dissolved the problem of incompatibility between the inorganic agent and organic resin matix. Poly(methoxyethylamine-co-hydroxyethyl methylacrylate phosphazene) and thiolation geltin was synthesized and made up an injectable hydrogel as a potential jaw restorative material through Micheal addition but not crosslinking by micromolecule agents. The effect of properties of hydrogel caused by different functional group ratio and polymer solution concentration were researched.