The Systematic Review Of Xuesaitong Injection Compared With Compound Danshen Injection For The Treatment Of Acute Cerebral Infarction

Objective:To comprehensively evaluate the curative effects of the combined medication on acute cerebral infarction with the combination of Xuesaitong injection and conventional drugs as the treatment group and the combination of compound Danshen injection and conventional drugs as the control group.Methods:With the language limited in Chinese and English, computers were used to comprehensively retrieve all the clinical data published at home and abroad from January,2009to December,2013in PubMed, Medline and Cochrane Control Experiment Center Database, Chinese Biomedical Literature Database (CBM), Chinese Journal Full-text Database (CNKI), VIP Database (VIP, China Scientific Journal Database) and Wanfang Data Resource (Digital Journal Full-text Database). Literatures related to the treatment of Xuesaitong injection on acute cerebral infarction were retrieved manually in Chinese Journal of Neurology, Journal of Stroke and Neurology, Neurological Diseases and Mental Health, Chinese Journal of Stroke, and Journal of Brain and Nerve Diseases, etc. Randomized control experiments of the treatment of Xuesaitong injection on Acute Cerebral Infarction as the treatment group and compound Danshen injection as the control group were included. The collected data were included for the primary study and the strict Jadad scoreing was performed with the assessment of methodology then. The data were extracted for meta-analysis using the RevMan5.2.7software provided by the Cochrane collaboration network.Results:There were a total of20studies included, including2046cases of patients that met the inclusion criterion, in which1060cases were in the treatment group and1013cases were in the control group with similar baseline situation. The Meta-analysis showed that:compared with the combination of compound Danshen injection and conventional drugs, the combination of Xuesaitong injection and conventional drugs had:1. A significantly increased total effective rate [OR=3.75,95%CI (2.88～4.90)] with a statistically significant difference (P＜0.00001);2. A significantly increased total efficiency rate [OR=3.28,95%CI (2.713.95)] with a statistically significant difference (P＜0.00001);3. A significantly increased total cure rate [OR=2.35,95%CI (1.90～2.89)] with statistically significant difference (P＜0.00001);4. The difference in terms of deterioration rate [OR=0.57,95%CI (0.27～1.19)] was not statistically significant.Conclusion:The study suggested that the Meta-analysis of the included20studies showed that compared with the combination of compound Danshen injection and conventional drugs, the combination of Xuesaitong injection and conventional drugs could increase the total effective rate, total efficiency rate and total cure rate for the included patients with acute cerebral infarction. However, the sample size in the study is relatively small and the overall quality level of the literatures is lower. In addition, all the20studies failed to conduct a long-term follow-up and standard recording of adverse reactions. Therefore, the conclusion above still needs verification through randomized control experiments of large sample size and high quality.