| Purpose:To study different doses of rhubarb the clinical cure effect of traditional Chinese medicine compound for the treatment of chronic renal failure, preliminary exploration rhubarb clinical use the most appropriate dosage, raise the clinical curative effect of treatment of chronic renal failure.Method:Into the group conform to a standard of patients with chronic renal failure, no rhubarb were randomly divided into control group, low dose group of radix et rhizoma rhei (3g), middle dose group (5g) rhubarb, high dose group of radix et rhizoma rhei (10g). Observe four groups before and after treatment in patients with renal function, blood routine, routine urine,24hours urinary protein quantitative, propagated, ALT, potassium,K+, and other aspects of your bowel movements, comprehensive curative effect evaluation and safety evaluation.Result:Without rhubarb clinical effective rate was33.33%in the control group, low dose group of the clinical effective rate was22.22%, doses of the experimental group in the clinical effective rate was50%, high dose group of the clinical effective rate was66.67%, the curative effect of rhubarb in different dose group showed a trend of concentration-response relationship, because of the small sample sizes, and there was no statistically significant difference between the groups. The control group with low, medium and high dose group of TCM symptoms have a certain amount of relief, but the base is too little, found no effect dose related. In4cases of stool stem node; Low dose group in1case of stool stem node; Defecate normal dose in test group. High dose group appear diarrhea (3cases), reduced to5g, defecate character, the number of all normal. This experiment suggests rhubarb optimum dose of5g.Conclusion:the curative effect of rhubarb in different dose group showed a trend of concentration-response relationship. Most suitable dose of rhubarb, still need to enlarge the sample size, longer follow-up period, to continue exploring. |
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