Relationship Between Cystatin C And Monocytes And Coronary Stenoses In Patients With Coronary Artery Disease

OBJECTIVE: We mainly investigated the correlation between the extent of coronaryarteries stenoses along with the number of monocytes and serum levels of cystatin C inpatients with stable coronary artery disease (SCAD) or acute coronary syndrome (ACS)but without overt chronic kidney disease especially with creatinine-derived eGFR≥90ml/min/1.73m2. We also simply analyzed the difference of some cardiovascular factorsbetween so-called normal people and CAD patients.METHODS: We studied307patients who all accepted coronary angiography. Thesepatients were chiefly divided into control group (n=106) and CAD group (n=201).Control group was ulteriorly categorized into normal group (n=65) and CMB group(n=41), while CAD group was further sectionalized into SCAD group (n=83) and ACSgroup (n=118). Factors which were deemed to have a possible effect on the formationand progression of atherosclerosis among groups were compared. We calculated scoresof coronary stenoses of all patients respectively according to Gensini scoring system,Jeopardy scoring system and Stenosis scoring system. Correlation between serumcystatin C levels and Gensini score, Jeopardy score or Stenosis score in SCAD and ACSgroup was respectively described in detail.RESULTS: For patients with eGFR≥90ml/min/1.73m2in ACS group, serum cystatin Clevel strongly and positively correlated with Gensini Score (r=0.949, P＜0.001), Jeopardy Score (r=0.870, P＜0.001) and Stenosis Score (r=0.705, P＜0.001). However,serum concentration of cystatin C had an intensively negative correlation with GensiniScore (r=0.991, P＜0.001), Jeopardy Score (r=0.850, P＜0.001) and Stenosis Score(r=0.865, P＜0.001) in SCAD patients with eGFR≥90ml/min/1.73m2. In patientswith ACS the number of monocytes had an intensively positive correlation with serumconcentration of cystatin C (r=0.382, P<0.001). However, no relation did exist inSCAD patients.CONCLUSION: Cystatin C would become a potential and helpful biomarker appliedto initially and simply estimating the extent of coronary stenoses in the selected patientsin the near future.