Correlation Between Serum Cystatin C Level And Severity Of Coronary Artery In Acute Coronary Syndrome

Objective: To study the correlation between cystatin C and severity of coronaryheart disease(CHD).Methods: One hundred and eighty-nine patients with ACS who underwentcoronary angiography during January2012and June2012in Crdiac Care Unit (CCU)of The First Affiliated Hospital of Dalian Medical University were included in our study.They were divided into two groups according to their history and clinical backgrounds:eighty-five patients with unstable angina pectoris were divided into the UAP group andthe rest with ST-segment elevated myocardial infarction were divided into STEMIgroup. Another seventy-four patients with no CHD (Suspected CHD clinically withnegative coronary angiography) served as a control group.The severity of CHD wasscored using the Gensini scoring system. The correlation between serum cystatin Clevel and severity of CHD with lesions of coronary arteries was analyzed.Results: The serum cystatin C level in UAP group was the highest while it was thelowest in control group.The serum cystatin C level was significantly higher in UAPgroup and STEMI group than in the control group（0.93±0.21mg/L vs0.89±0.25mg/Lvs0.75±0.25mg/L,P＜0.05), but no significant difference was found between STEMIgroup and UAP group. The average Gensini score in the control group was5.45±1.75points and there was no correlation between serum cystatin C level and their Gensiniscore. On the contrary, there is positive correlation between serum cystatin C andGensini score（r=0.327，P=0.013） in ACS group (composed of UAP group and STEMIgroup) in which the mean average Gensini score was45.5±25.65points. Patients withtriple vessel disease have higher serum cystatin C levels and Gensini scores than thosewith single or double vessel disease. Patients with double vessel disease have higherGensini score than those with single vessel diease, but there in no difference betweentheir serum cystatin C level.Conclusion:Cystatin C level is significantly correlated with the severity of CHD and can thus be used as a new marker in assessing the severity of CHD.