Impact Of Combined Application Of N-terminal Pro-B-type Natriuretic Peptide And Doppler Echocardiography And Blood Gas Analysis On The Diagnosis And Prognosis In Patients With Acute Left Heart Failure

Objective: To explore the Diagnostic value and the impact of combinedapplication of N-terminal pro-B-type natriuretic peptide（NT-proBNP） andDoppler echocardiography and blood gas analysis on the averagehospitalization days and the prognosis in patients with acute left heart failure.Methods: A total of96patients with acute left heart failure admitted inour cardiovascular department from Jan.2008to June.2010were enrolled ingroup A (control group1) who were measured Doppler echocardiography andblood gas analysis but not measured NT-proBNP；A total of98patients withacute left heart failure admitted in our cardiovascular department fromJuly.2010to Dec.2013were enrolled in group B (experimental group) whowere measured Doppler echocardiography and blood gas analysis andNT-proBNP; A total of54patients without acute left heart failure admitted inour cardiovascular department from July.2010to Dec.2013were enrolled ingroup C (control group2) who were measured Doppler echocardiography andblood gas analysis and NT-proBNP. Diagnostic datas of the latter two groupswere recorded and analysised. The previous two groups patients werefollowed up for6months. The previous two groups of the averagehospitalization days, readmission rate, mortality rate and the average hospitalization expenses were compared.Results:Combined application of NT-proBNP detection, Dopplerechocardiography and blood gas analysis diagnosis mode can be achieved93.4%of accuracy in diagnosis of acute left heart failure，which is higher thandiagnostic accuracy of the combined application of NT-proBNP andDoppler echocardiography(90.1%),NT-proBNP used alone(82.8%) orDoppler echocardiography used alone (76.3%). In group B, the averagehospitalization days of8.2±0.9days is shorter than that of A group which is11.1±0.8days (P<0.05). B group readmission rate was9.2%, mortality was5.1%,which is lower than that of A group readmission rate was15.6%, themortality was9.4%(P<0.05). In group B, the average hospitalizationexpenses of9324±462yuan is lower than that of group A which was12315±574yuan (P<0.05).Conclusion: Using a combination of NT-proBNP detection, Dopplerechocardiography and blood gas analysis can improve the accuracy ofdiagnosis of acute left heart failure, and can reduce the average days ofhospitalization in patients with acute left heart failure, improve the prognosisand save the cost of hospitalization.