| BackgroundsHeart failure(HF,hereinafter referred to as heart failure)is a group of complicated clinical syndromes caused by any structural or functional abnormality of the heart leading to impaired ventricular filling or ejection ability.Its main clinical manifestations are dyspnea and asthenia(motility tolerance).Restricted),and fluid retention(pulmonary congestion and peripheral edema).HF is divided into acute heart failure(AHF)and chronic heart failure(CHF).Acute heart failure refers to the rapid occurrence or worsening of symptoms and signs of heart failure [1].The poor prognosis of AHF,rehospitalization rate,and mortality are high [2].Therefore,it is particularly important to objectively evaluate the prognosis of acute heart failure.B-type N-terminal pro-brain natriuretic peptide precursor(NT-proBNP)is a neuroendocrine that is mainly synthesized and secreted by ventricular myocytes.At the time of AHF,NT-proBNP is largely secreted by the left ventricle due to increased ischemia or wall tension,and its level is an important indicator for the diagnosis and prognosis of AHF.The purpose of this study was to investigate the relationship between plasma NT-proBNP levels and the prognosis of AHF patients.ObjectiveCompare the basic information and data of the different enrolled patients,relevant test examination indicators,observe the major cardiovascular adverse events within 6 months of different AHF patients,and explore the relationship between plasma NT-pro BNP levels and the prognosis of AHF patients.MethodsA total of 200 patients with acute heart failure admitted to the Department of Cardiology at the First Affiliated Hospital of Zhengzhou University from October 2015 to April 2017 were selected,including 89 males and 111 females,aged 38-83 years.On the 1st and 5th day after admission,plasma NT-proBNP concentrations were measured,and the rate of decline of NT-pro BNP was calculated for each patient.According to BNPtest results,the patients were divided into two groups.Group A was admitted to hospital with NT-proBNP ?500 ng/L,and BNP after 5 days.The rate of decline was ?30% in 103 patients.In group B,NT-proBNP was ?500 ng/L.After 5 days,the rate of BNP reduction was <30% in 97 patients.The left ventricular ejection fraction(LVEF)and left ventricular end-diastolic dimension(LVEDd)of each patient were measured on the first day of hospital admission and 6 months after discharge.The patients were followed up and recorded for adverse cardiac events within 6 months after they were admitted to hospital.All data were analyzed using SPSS21.0 statistical software.Measured data were expressed as mean±standard deviation(x±s),and t-test was used for comparison between groups.The number of count data is represented by the number of cases(percentage)and the c2 test is used for comparison between groups.P<0.05 was considered statistically significant.Results1.There was no significant difference in gender,age,body mass index,smoking history,hypert-ension,hyperlipidemia and diabetes between the two groups(all P> 0.05).2.The difference of NT-proBNP on the 1st d was not statistically significant between 2 groups(P <0.05).On the 5th d,NT-pro BNP decreased in group A compared with group B[(3259.03±3508.79)%vs(6388.30±5503.96)%,P < 0.05].The decreasing rate of NT-pro BNP in group A was significantly higher than that in group B [(51.44±13.63)% vs(16.37±6.39)%,P <0.05].3.On the 1st d,the difference in LVEF had no statistically significant between 2 groups(P <0.05),LVEDd decreased in group A compared with group B [(50.47±8.00)%vs(53.16±7.61)%,P<0.05].After 6 month,LVEF increased in group A compared with group B [(52.26±6.09)%vs(47.57±7.35)%,P < 0.05].LVEDd decreased in group A compared with group B [(51.46±8.16)%vs(54.96±7.72)%,P<0.05].4.Six months after follow-up,the incidence of recurrent cardiovascular events and heart failure in group A was significantly lower than that in group B,the difference was statistically significant(P <0.05).ConclusionThe declining rate of NT-proBNP can be used as an important reference index to judge the prognosis of patients with acute heartfailure. |
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