Effect Of The Tranexamic Acid On The Blood Loss After Primary Total Knee Arthroplasty

Objective Investigate the effects of the use of tranexamic acid (TXA) on blood loss in primary total knee arthroplasty surgery patientsMethods Chose total43patients from June2012to June2013(11males,32females; aged55-85years, averaged65years) underwent total knee arthroplasty (TKA). All of the patients were osteoarthritis. They were divided into Group A (n=22) and Group B (n=21). The patients in Group A received1g of tranexamic acid dissolved in100ml of normal saline was intravenously infused before deflation of the tourniquet, and the patients in Group B received an equal volume of normal saline. We measured the blood loss, blood transfusion of all the groups, and carried out the comparative analysis. Then also observed for whether patients had deep vein thrombosis and pulmonary embolismResults The visible blood loss was103.80±31.90ml in Group A and137.61±63.19ml in Group B, there was significant difference between the two groups(p<0.05). The hidden blood loss was73.74±78.37ml in Group A and329.78±184.12ml in Group B, there was significant difference between the two groups(p<0.05).There was no significant difference in occurrence of deep vein thrombosis, pulmonary embolism among the study groupsConclusion The tranexamic acid may reduce visible and hidden blood loss in patients undergoing total knee arthroplasty, without increasing the risk of deep vein thrombosis, pulmonary embolism.