| Objective(s):This study was to investigate the clinical efficacy and safety of sucrose iron combined with sucrose iron in total knee arthroplasty(TKA).Methods:June 2016 to July 2017,180 patients were enrolled in this study and randomly assigned to combined ranexamic acid group(combined group),tranexamic acid group and iron group.Record replacement at admission,the day before surgery,after surgery,three,five days of hemoglobin concentration,hematocrit.The number of blood loss,postoperative drainage and postoperative blood transfusion were recorded.Besides,the amount of preoperative blood volume,total blood loss were recorded.Results:The average age of the patients was 65 years.All preoperative data were not statistically significant(P>0.05).The levels of preoperative hemoglobin in combination group and iron group were significantly higher than those in group tranexamic acid group(P<0.05).At the same time,the blood loss and total blood loss were significantly lower in the combined group than in the group(P<0.05).There were no complications such an infection,deep vein thrombosis,pulmonary embolism during follow-up.Conclusion(s):(1)Combined ues of iron and tranexamic acid can effectively increase the total knee Arthroplasty,perioperative hemoglobin concentration signification reduced blood loss,greatly decrease the blood transfusion,and dose not increase the risk of postoperative lower limb deep vein thrombosis.(2)In perioperative application of total knee arthroplasty,iron agent,can quickly improve hemoglobin content,enhance patient tolerance for orthopedic surgery,reduced from the blood transfuxion related complications,shorten hospitalization time,promote the patients postoperative rehabilitation.(3)In perioperative application of total knee arthroplasty,tranexamic acid,can significantly reduce the loss of perioperative hemoglobin,reduce the incidence of postoperative anemia,promote patients postoperative rehabilitation,and dose not increase the risk of postoperative thrombosis. |
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