Clinical Study Of^99mTc-MIBI In Microwave Ablation Efficacy Evaluation Of Treatment NSCLC

ObjectiveThe percutaneous microwave coagulation therapy (percutaneous microwavecoagulation therapy,PMCT) for the treatment of non small cell lung cancer (non-small celllung carcinoma, NSCLC) review analysis of the recent curative effect, because on99m-estamibi(99mTc-methoxyisobu-1isonitrile,99mTc-MIBI) lung tumor imaging efficacy ofpercutaneous microwave coagulation therapy in lung cancer evaluation of the value ofclinical application.MethodsRetrospective analysis of2012April to2014March in No.88Hospital of PLA fromcancer center,42patients received PMCT treatment and complete data of patients withNSCLC.In the PMCT before treatment and1months after treatment respectivelyunderwent99mTc-MIBI imaging of lung tumor lesions,choose clear level in tomographicimages,according to the shape of the delineation of lesions of region of interest (ROI),thecontralateral normal lung tissue equivalent position in region of interest as a controlarea,are calculated respectively.The early uptake ratio of tumor/non tumor tissue (ER) anddelayed uptake ratio (DR).The PMCT before and after treatment,ER value,DRvalue,parallel statistics analysis.Efficacy and safety evaluation of PMCT in the treatment ofNSCLC.ResultsPMCT treatment of42cases of NSCLC patients.(1)99mTc-MIBI lung tumor imagingobservation:before treatment the99mTc-MIBI lung tumor imaging, calculated ER valuesranged from1.88to3.12,average2.08±0.20,DR value is1.80~3.10,with an average of2.04±0.21.After the treatment of1menstrual99mTc-MIBI lung tumor imaging calculatedER values ranged from1.47to3.10, average1.96±0.31,DR value is1.35~3.09,with anaverage of1.92±0.32.The statistical analysis showed that PMCT treatment after NSCLCtreatment ER value decreased significantly,with statistical significance,P<0.01.After treatment,DR value decreased significantly,with statistical significance,P<0.01.If thedecline in value of ER before and after treatment and the rate of DR≥10%as observationindex,can be found decreased ER value before and after PMCT treatment rate of NSCLCwas10.4%,a decrease in DR rate is11.1%,drop rate changes significantly.(2)PMCTpulmonary CT observation of treatment of NSCLC before treatment,after1months,6months after treatment were measured lung CT lung cancer tumor maximum diametercalculation for tumor size,tumor size was measured before treatment was2.20~6.70cm,anaverage of3.93±1.26cm, the size of tumor1months after the treatment of measurement2.50~6.50cm,an average of3.95±1.10cm,the size of tumor6months after the treatment ofmeasurement is2~6.48cm,an average of3.76±1.24cm.Display1months after treatmentcompared with before treatment,tumor size was not reduced,but increased slightly,but therewas no significant difference between the P>0.05.6months after treatment compared withbefore treatment,the tumor size decreased significantly,the difference was statisticallysignificant,P<0.01.After6months of treatment and1months after treatment,phasecomparison,tumor size decreased significantly,the difference was statisticallysignificant,P<0.01.(3)the quality of life (QOL):the fractional values of KPS score asobservation indexes,respectively in42patients before treatment, after treatment for1months,6months after treatment,KPS score,respectively67.38±7.01,70.71±8.94,72.62±6.65.1months after treatment,the patient’s quality of life improved,with statisticalsignificance before treatment,after treatment of1phase difference,P<0.01.6months aftertreatment,compared with the1months before and after the treatment, the patient’s qualityof life has been further improved,the difference was statistically significant,P<0.01.(4)adverse reactions:the main side effects were fever,cough,chest pain,fatigue,pneumothorax,hemoptysis,pleural effusion,infection,skin burns.The fever, the incidence ofchest pain with statistical difference before and after treatment, P<0.01.But thecough,fatigue,pneumothorax,hemoptysis,pleural effusion,infection of skin burns,there wasno significant difference,P>0.05.The above adverse reaction after active treatment in5to14days were recovered.42cases of heart and lung and kidney failure,all did not appear inPMCT treated patients with severe pulmonary or systemic infection and secondary fungusinfection,severe bleeding complications and even death.Conclusion99mTc-MIBI lung tumor imaging can better evaluate the efficacy of PMCT intreatment of NSCLC,the active degree can reflect the treatment of lung cancer,and has theadvantages of non-invasive,safe,simple and economic,the preferred way can be used as PMCT treatment NSCLC curative effect evaluation.