The Changes Of Multiple Sclerosis Cognitive Impairment In Attention Deficit And Event Related Potentials

Objective: this paper aims to study the changes ofMultiple Sclerosis cognitive impairment in attention deficit and event-related potentials, neuropsychology and event-related potentialapplication value in the early diagnosis of MS, to improve the earlydiagnosis level of MS. Methods: Chose30patients were screened as MSpatient group, the patients are outpatients and hospitalized patients in2013October to2014February in Luzhou Medical College, all patientsfulfilled the McDonald criteria, and confirmed by head MRI examination,and30matching people were chosen as normal control group at the sametime. All subjects were tested through the HAMA and HAMD to rule outthe depression and anxiety, and completed the following tasks:1,neuropsychological tests: Mini-Mental State Examination (MMSE);Montreal Cognitive Assessment (MoCA).2, the computer aided test:1.Sustained attention test (CPT),2. Selective attention test (STROOP),3.Metastatic attention test (TMT-B),4. Divided attention test (PASAT).3,event-related potentials: Contigent Negative Variaeion (CNV) and P300.Finally, analyze the correlation. Result:1.the differences in general datasuch as gender, age, years of education between MS patient group andnormal control group were no statistical significance.2.In the MMSE test,the MMSE scores in memory, attention and calculation of the MS patient group were statistically lower than those of the normal control group. Andin the MoCA test, the MoCA scores in recent memory, attention,information processing speed and visual spatial ability executive functionof the MS patient group were also lower than those of the normal controlgroup.3.Computer aided neural psychology test results showed,1）In theContinuous Performance Task (CPT), the MS patient group comparedwith the normal control group, the average response time was extending,and the false negative rate increased in the severe group increasedsignificantly. The differences were statistically significant. Sustainedattention was damaged obviously.2）in the Stroop test, the MS patientgroup were compared with the normal control group, reaction time wereprolonged,interfered effect were increased, but the differences were notstatistically significant. The selective attention of MS patient group wasnot obviously damaged.3）In the part of TMT-B, the MS patient groupcompared with the normal control group, the number of time-consumingincreased significantly. The difference was statistically significant. TheMetastatic attention of the MS patient group was damaged obviously.4）In the PASAT, compared with the normal control group, the scores of theMS patient group decreased. The difference was statistically significant.The divided attention of the MS patient group was damaged obviously.4. Event-related potentials demand that in the MS patient group, thelatency of N2, P3, CNV were prolonged, and the volatility decreased significantly.5. The correlation analysis:(1) P300,CNV and CPT:1)Thecorrelation analysis showed that the latency of N2, the latency andamplitude of P3and CNV have good correlation with CPT. There was apositive correlation between the latency of N2, P3, EW and the reactiontime in CPT of the MS patient group. There was a negative correlationbetween the amplitude of P3and EW, the area of EW and the reactiontime in CPT.2) The correlation analysis showed that the latency of N2,the latency and amplitude of P3and the latency and amplitude and thearea of EW had good correlation with CPT. There was a positivecorrelation between the latency of N2, P3and the false negative rate inCPT of the MS patient group. There was a negative correlation betweenthe amplitude of the P3and EW and the area of EW and the falsenegative rate in CPT.(2) P300, CNV and TMT-B: The correlationanalysis showed that the latency of N2, the latency and amplitude of P3and CNV have good correlation with TMT-B. There was a positivecorrelation between the latency of N2, P3, EW and the testing time inTMT-B of the MS patient group. There was a negative correlationbetween the amplitude of P3and EW and the area of EW and the testingtime in TMT-B.(3) P300, CNV and PASAT:1)The correlation analysisshowed that the latency of N2, the latency and amplitude of P3and CNVhave good correlation with PASAT. There was a negative correlationbetween the latency of N2, P3, EW and the scores in PASAT of the MS patient group. There was a positive correlation between the amplitude ofthe P3and EW and the area of EW and the scores in PASAT. Theattention disorder of the MS patient group may be related to thefrontotemporal cortex thinning. Conclusion:1. Patients with MScognitive impairment, the fields of cognitive impairation were wide,especially in information processing speed, visual learning and visualmemory, and attention (sustained attention, metastatic attention, dividedattention) damage already existed.2. Neural psychology test: CPT, Stroopand TMT-B, PASAT showed that the sustained attention, metastaticattention, divided attention are damaged.3, The correlation analysisshows that, P300and CNV have good correlation with CPT, TMT-B andPASAT. So P300and CNV can also be used as supplementary means forthe impairment test of attention of the MS patient.4, In the MS patient,P300is more sensitive than CNV, so P300can be used as a goodindicator of MS. P300and CNV can both test the impairment of the MSpatient with the neural psychology test.