A Systematic Review Of Nourishing Yin And Tranquilizing In The Treatment Of Insomnia

Purpose: Through Systematic review and meta analysis on nourishing yin and tranquilizing therapy for insomnia,to provide reliable evidence for clinical application of nourishing yin and tranquilizing therapy for insomnia.Method: Through the search of electronic databases and manual searching,From 2015 to January published in medical journals, dissertations and conference, but in order to get unpublished randomized clinical trials research literature on Nourishing Yin and tranquilizing therapy for insomnia clinical data in the literature,Screened the literatures met the inclusion criteria were collected, and carries on the analysis to the literature from two aspects of qualitative and quantitative.2 reviewers according to the Cochrane collaboration evaluation of literature quality requirements with the Jadad scale list and summarize the characteristics of clinical research and the quality of the included studies was evaluated and described in the literature.Quantitative analysis of literatures were in accordance with the effect of the amount of combined statistics, using Rveman5.3 for meta analysis.Result: The search to 233 related literatures, eventually completely met the inclusion criteria 18 literatures were collected, all Chinese literature.In the literature of randomized clinical trials and 13 randomized controlled trials, half for 5, B grade quality of literature 5articles, 13 articles of C.13 randomized controlled clinical trials in meta analysis, results showed that: the "guiding principles of clinical research on new drugs of TCM group" OR =2.99, 95% confidence interval CI is [1.94, 4.61], with statistically significant difference between the two groups, the treatment group(P<0.00001, nourishing yin and tranquilizing)the total effective rate of the control group(Western medicine or is the placebo group) 2.99times; "Standard" of diagnosis and therapeutic effect of TCM group OR = 8.48, 95%confidence interval CI is [3.34,21.52], with statistically significant difference between the two groups, the treatment group(P<0.00001, nourishing yin and tranquilizing) total effective rate of control group(Western medicine or placebo)8.48 times; "Treatment" guiding principles of clinical research on new drugs in the group of 14-15 OR = 4.34, 95% confidence interval CI is [2.24,8.43], with statistically significant difference between the two groups, the treatment group(P<0.0001, nourishing yin and tranquilizing) total effective rate of control group(Western medicine or placebo) 4.34 times; "Treatment" guiding principles of clinical research on new drugs in group 28-30 OR = 2.04, 95% confidence interval CI [1.05,3.98], with statistically significant difference between the two groups, P=0.04<0.05 treatment group(yin and tranquilizing) total effective rate of control group(Western medicine or placebo) 2.04times;Estazolam Tablets drug control group OR = 3.51, 95% confidence interval CI is[1.80,6.84], with statistically significant difference between the two groups, the treatment group(P=0.0002<0.05, nourishing yin and tranquilizing) total effective rate of control group(Estazolam Tablets) 3.51 times.Conclusion:The study included a total of 18 papers, 13 papers in the final analysis meta.The literature on methodological quality is low. The Meta analysis results showed that: The treatment group(yin and tranquilizing mind) in treatment of insomnia in the total efficiency was significantly higher compared with the control group(Western medicine or placebo); "guiding principles of clinical research on new drugs of TCM group" treatment for 14-15 days and 28-30 days, the treatment group(yin and tranquilizing) total effective rate than the control group(Western medicine or placebo); "guiding principle of clinical research on new drugs of TCM" in the group treatment group(yin and tranquilizing) the total efficiency is higher than that of the control group(Estazolam Tablets).One of the most important method of nourishing yin and tranquilizing Chinese medicine as a therapy for insomnia,the experimental study on clinical randomized control literature generally low methodological quality,design is not strict standards,the sample size is too small, single center study, does not use the blind method,the literature on the reliability and authenticity of the poor, the presence of publication bias and heterogeneity, thus providing evidence for clinical scientific decision making poor.