Study Of Camel Milk On Type â…¡ Diabetes Mellitus Model Of Rat Erythrocyte Membrane Antioxidant

In this paper,to study the anti diabetic effect of camel milk,with type Ⅱ diabetes rats as diabetic model, by giving a certain dose of camel milk, tracking detection of the index correlated with diabetes to explore the effect of camel milk on antioxidant activity of red cell membrane in type Ⅱ diabetic rats model.Clean level male Wistar rats were divided into two groups after one week adaptation period:One group was the blank control group (K), the other group was the model group (Z).The model group (Z) was built up with high glucose high fat diet and injection of streptozotocin (STZ) to establish the degree of type Ⅱ diabetes model. In a week with injection of STZ, the model group (Z) fasted overnight, and then tail vein blood samples were collected to measure fasting blood glucose (FBG). type 2 diabetes model success criteria was FBG≥11.1mmol/LThe model group (Z) were divided into diabetic model group (M), positive drug group (W), camel milk treated group (T). M group fed with 200mg/kg dose of saline, W group fed with 200mg/kg dose of metformin hydrochloride tablets, T group fed with 60mg/kg orally camel milk, blank group fed with 200mg/kg dose normal saline. During this period following with weekly measurement of body weight and fasting blood glucose content of the test rats and recording. Making the measurement of antioxidant index of red cell membrane SOD、GSH-Px、CAT and MDA every 2 weeks. Evaluating Serum cholesterol (CHO), triglyceride (TG), high density lipoprotein (HDL), low density lipoprotein (LDL) 11 weeks later. The control group (K) compared with the model group, positive drug group and camel milk treatment group, serum CHO, TG, LDL are elevated, HDL reduces significantly different (P<0.05). Compared with the model group, the CHO, TG, HDL of camel milk treatment group and positive drug group decreased, LDL increased, the difference was significantly (P< 0.05). Comparison of the other three groups, erythrocyteSOD, GSH-Px, CAT activity was significantly reduced with the control group (K), MDA content increased (P<0.05). Compared with the model group, treatment group and drug group of camel milk on erythrocyte membrane SOD, GSH-Px, CAT activity was significantly increased, MDA content decreased (P< 0.05).