| Objective:To investigate the association of hemoglobin(Hb), hematocrit (HCT) level with the cardiac function, cardiac structure, inflammatory reaction medium in patients with chronic heart failure and its possible mechanism by studying the correlation among Hb, HCT with NYHA classification, cardiac systolic and diastolic function, cardiac structure and high-sensitivity C-reactive protein(hs-CRP) in patients with chronic heart failure. Methods:Seven hundred and eighty patients with chronic heart failure in our hospital between January 2013 and August 2014 were analyzed retrospectively. Of seven hundred and eighty patients with chronic heart failure, four hundred and eleven patients were included in our study accorded with inclusion and exclusion criteria. Each patient received examinations of blood routine, blood biochemistry, echocardiography and hs-CRP. The clinical datas of patients were recorded. According to the different values of Hb and HCT, the patients were divided into groups respectively., and the differences of the general clinical data, blood biochemistry, cardiac structure and function of patients were compared and analyzed in each group. According to the different values of hs-CRP, the patients were divided into two groups, and the differences of Hb and HCT of patients were compared and analyzed in each group. Date analysis was performed by using the Statistical Package for Social Sciences(SPSS17.0). The value of P<0.05 was considered significant for all tests. Results:(1) According to the different Hb, from group A to group C, with a progressive decrease in Hb level, NYHA class increased gradually(P<0.01). From group A to group C, with a progressive decrease in Hb level, there was significant difference in LVEF among the three groups (P<0.01). Hb level correlated positively with LVEF, r=0.291, the linear regression equation obtained was LVEF=0.171 (Hb)+28.936, P<0.01. (2) According to the different HCT, from group 1 to group 3, with a progressive decrease in HCT level, NYHA class increased gradually(.P<0.01). From group 1 to group 3, with a progressive decrease in HCT level, there was significant difference in LVEF among the three groups of (P<0.01). HCT level correlated positively with LVEF, r =0.251, the linear regression equation was obtained LVEF=0.484(HCT)+31.835, P<0.01. From group 1 to group 3, with a progressive decrease in HCT level, there was significant difference in left atrial diameter among the three groups (P<0.05). HCT level correlated inversely with left atrial diameter, r=-0.100, (P<0.05), the linear regression equation was obtained, left atrial diameter=-0.148(HCT)+47.812, P<0.05. (3)There were linear correlation among Hb, HCT and hs-CRP, r was -0.291,-0.302 respectively, the linear regression equation was Hb=-0.345 (hs-CRP)+133.598、HCT=-0.110 (hs-CRP)+41.198 respectively, P<0.05. Conclusion:Hb and HCT correlated with the change of cardiac function in patients with chronic heart failure. With a progressive decrease in Hb, HCT, NYHA class increased gradually, LVEF decreased gradually and cardiac function decreased gradually. With a progressive decrease in HCT, left atrial diameter increased gradually. Hb and HCT had a inverse correlation with hs-CRP. This indicates that the decrease of Hb and HCT level may be related to the inflammation in patients with chronic heart failure. |
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