Efficacy Of Neoadjuvant Therapy ForⅡ, Ⅲ Midterm Low Rectal Cancer

Objective:To evaluate the results of neoadjuvant therapy, surgery and adjuvant therapy for Ⅱ, Ⅲ midterm low rectal cancer, and analysis of treatment outcomes for each of the class patients. Methods:Retrospective analysis the data of Ⅱ, Ⅲ midterm low rectal cancer patients (T3, T4 or N1, N2) between January 2009 to December 2013 in Xinjiang Medical University Cancer Hospital. According treatment divide them into the neoadjuvant and surgery group and the surgery and postoperative adjuvant therapy group. The neoadjuvant and surgery group was enrolled 98 patients, who were with radical resection following preoperative concurrent chemoradiotherapy, and the surgery and postoperative adjuvant therapy group was enrolled 93 patients, who were with postoperative adjuvant therapy after radical surgical resection. Followed the patients until December 2014, and the median follow-up time is 38 months. And make a comparison about the efficacy and effects of different treatments on survival of patients. Results: The 1 year,2 years and 3 years of local recurrence rate and the distant metastasis rat of the neoadjuvant and surgery group is lower than the surgery and postoperative adjuvant therapy group. There is significant difference between the two groups (P=0.675),but except the 1 year distant metastasis rat(P=0.675). Also the neoadjuvant and surgery group survival is better than the other group. The 1 year survival rate and disease-free survival rate is no significant difference (OS:P=0.675; DFS:P=0.129), but there is significant difference inthe 2 years and 3 years survival rate and disease-free survival rate between the two groups(P=0.675).The incidence of complications is higher in the neoadjuvant and surgery group than the others, but there is no significant difference between the two groups(P=0.413) Conclusion:For patients with Ⅱ, Ⅲ midterm low rectal cancer, the neoadjuvant therapy can significantly reduce the rate of local recurrence, distant metastasis and prolong survival, and it is a safe and reliable treatment.