Clinical Research In Patients With Cerebral Microemboli On Trans Cranial Doppler Ultrasound Monitoring

Objective:cerebral infarction (cerebral infarction, CI) underwent micro-emboli signal (Mi croemblic Signal, MES) monitor, investigate cerebral microemboli monitoring and differen t subtypes of stroke risk factors, treatment and monitoring of time-related relationship.Methods:in August 2013-August 2014 into Angang General Hospitalof 83cases of isch-emic stroke neurology hospital, were diagnosed by brain CT or MRI, and in accordance wi th the Fourth National Cerebrovascular Disease Conference revised diagnostic criteria for c erebral infarction. Collect clinical information and improve transcranial Doppler ultrasoun d, brain MRI and MRA, neck CT angiography, cardiac ultrasound examination of patients with subtype CI group, to carry out the blood of patients with microemboli signals indicato rs for monitoring and surveillance using Statistical Package for Social Sciences SPSS 18.0 f or all data collected in this study data analysis, monitoring and cerebral microemboli explo re different subtypes (based on low molecular weight heparin in acute stroke therapy trials cause typing method (The Trial of Org 10172 in Acute Stroke Treatment, relationship type TOAST) classification), stroke risk factors, treatment and monitoring of the relevant time.I n 70 cases collected in our hospital were diagnosed by CT or MRI examination was normal and the gender, age matched healthy subjects as control group. Comparison of incidence of two groups of microemboli positive detecting rate and 6 months of ischemic cerebrovascular events.Results:Both groups were gender, age, comorbidities (hypertension, diabetes, coronary he art disease), the smoking history, drinking history, lipid levels (cholesterol (TC), triglyceri de (TG), high density lipoprotein (HDL), low-density lipoprotein (LDL)) fibrinogen (Fib), high-sensitivity C-reactive protein (hs-CRP) and white blood cell count (WBC) and other i ndicators of the difference was not statistically significant (P> 0.05). Positive group of patients with uric acid (Uric) levels were significantly lower than the neg ative group, glucose (Glu) levels higher than the negative group, the difference was statisti cally significant (P<0.05) between the two groups. NIHSS score higher than the negative-positive group, but no significant difference between groups (P> 0.05). NIHSS score B‰¤4 points microemboli monito0.ring of patients positive for three cases, accounting for 5.88% (3/51); NIHSS score of 5 to 15 minutes of patient monitoring microemboli positive 4 case s, accounting for 16%(4/25); NIHSS score> 15 points microemboli monitoring of patients positive for one case, accounting for 14.29%(1/7), the difference between groups was not statistically significant (P> 0.05). According to TOAST classification into large artery athe rosclerosis (large-artery atherosclerosis, LAA) 42 cases of small artery occlusion (small-art ery occlusion, SAO) 24 cases of cardiogenic embolism (cardioembolism, CE) 15 cases, no other determined etiology (acute stroke of other determined etiology, SOE) cases of undete rmined etiology (stroke of other undetermined etiology, SUE) 2 cases. LAA which type mi croemboli monitoring positive in 6 cases, accounting for 14.29%; SAO microemboli monit oring positive type 1 cases, accounting for 12.5%; CE type microemboli monitoring positiv e one case, accounting for 6.67%, the difference between groups was not statistically signif icance (P> 0.05).The observation group MES monitoring was positive in 8 cases, control group MES monitoring was positive in 0 patients, the difference was statistically significant (P< 0.05); the observation group occurred within 6 months of ischemic cerebrovascular events in 15 cases, the control group occurred within 6 months of ischemic cerebrovascular events in 2 cases, statistically significant differences between groups (P< 0.05).Conclusion:1 patients with high blood glucose monitoring of microembolus positive rate is higher, more common in patients with large artery atherosclerotic stroke;2.The positive rate of microembolic monitoring in patients with cerebral infarction and 6 months the incidence of ischemic cerebrovascular events were higher;3.The positive rate of 3.MES detection by the onset time, drug use, case selection bias, the patient’s own reason and many other factors, can be used as auxiliary means in diagnosis of stroke etiology, and can be used for the treatment and prevention of the disease of the guide.