Clinical Observation On Treating Primary Nephrotc Syndrome Of Yangdeficien By Constitution Strengthening Healthy Energy And Warming Yang

Objective:Observation of Strengthening healthy energy and warming yang method for Yang deficiency constitution of primary nephrotic syndrome in children with biased constitution state intervention, for TCM constitution differentiation treatment and provide a theoretical basis.Methods:According to the ancient and modern physicians for a description of the children of Yang deficiency constitution, combined with clinical research, summed up the Yang deficiency constitution are susceptible to disease and physical characteristics, proposed Strengthening healthy energy and warming yang method and on the therapy treatment of Yang deficiency constitution primary nephrotic syndrome in children with clinical observation.30 cases of primary nephrotic syndrome were selected, and the constitution of TCM was a child with Yang deficiency constitution, and the observation method was adopted before and after self-control. All included patients were given routine western medical therapy, while giving children with self-made traditional Chinese medicine decoction for Warming Kidney Decoction orally. The course of treatment was 6 months and select 10 healthy children as normal control group, as in peripheral blood CD4+, CD8+T cell subsets in normal values. Observation before and after treatment with TCM Constitution score,24 hours urine protein, plasma albumin, cholesterol, serum IgG, and peripheral blood CD4+and CD8+T cells subsets and laboratory indexes changes, and statistical analysis.Results:1.The total effective rate of the children treated by the trial was 86.67%, and the transformation of TCM constitution was better than that of the treatment (P<0.05) before treatment.2.After treatment,24 h urine protein was significantly reduced (P<0.05) than before treatment, and plasma albumin was significantly higher than before treatment (P<0.05), cholesterol was lower than before treatment (P<0.05).3.After treatment compared with before treatment, the content of IgG in serum increased significantly (P<0.05) and peripheral blood CD4+T cells increased significantly compared with those before treatment, peripheral blood CD8+T cell level compared with those before treatment reduce(P<0.05), before and after the treatment of peripheral blood CD4+,CD8+T cells and normal control group(P<0.05), with statistical significance.Conclusions:1.The PNS of children in the literature and the process of the clinical evidence is common with Yang deficiency constitution.2. Strengthening healthy energy and warming yang method adjustment of Yang deficiency constitution, can reduce the constitution of Yang deficiency constitution with integral transformation, improve the children with partial constitution.3. Strengthening healthy energy and warming yang method can significantly reduced children 24 hours urine protein, cholesterol and peripheral blood CD8+T cell level, elevated plasma albumin and IgG in serum and peripheral blood CD4+T cell level, improve immune function.