| Objective: The aim of the present study was to screen the insertion/deletion polymorphisms(INDELs) which were suitable for forensic applications in eastern Chinese Han population.Methods: Polymerase chain reaction(PCR) and non-denaturing polyacrylamide gel electrophoresis were used to type the INDELs and population genetic parameters of these polymorphisms were obtained by the statistical analysis.Results: We obtained 20 polymorphisms which were suitable for forensic application in eastern Chinese Han population. Allelic frequencies were obtained for these polymorphisms. Our results revealed that all these INDELs were polymorphic in which the lowest minimal allelic frequencies(MAF) was 0.108. The combined discrimination probability(CDP) and combined exclusion probability(CEP) for the 20 INDELs were 0.999 993 845 and 0.916, respectively. The CDP and CEP for the 11 INDELs with MAF>0.3 were calculated to be 0.996 258 773 and 0.814 27,respectively.Conclusion: Our study provided at least 11 candidates INDELloci for forensic application in eastern Chinese Han population. |
