| Objective: Research of hypertension cerebral hemorrhage patien ts with peripheral blood interleukin 6(IL 6) and tumor necrosis fac tor related apoptosis inducing ligand(TRAIL) the expression of peri pheral blood on the initial level to explore whether these cytokines involved in hypertension cerebral hemorrhage patients with cerebral hemorrhage after what happened with a series of pathophysiological process.And to discover if there is a relationship between IL-6,T RAIL and Hypertensive cerebral hemorrhage.Models: Select October 2013- December 2014 in our hospital t reatment 60 patients with hypertensive cerebral hemorrhage patients as research subjects of the experiment,the subjects are in line withthe diagnostic criteria of hypertensive intracerebral hemorrhage(with a history of hypertension, admission higher than normal blood pr essure measurement),2.all patients have been diagnosed with brain CT scan of brain hemorrhage, and basal ganglia hemorrhage bleedin g sites are not broken into the ventricle, but not for surgery patie nts.And the Hematoma volume between 40 to 105 ml, average bloo d loss 50+-7 ml.3.Age of the patients were between the ages of 40 ~ 70. 4.All of the patients all belong to the onset of the first ti me. Exclusion criteria were:1.intracranial hemorrhage caused by tra uma.2.the patients with ruptured intracranial aneurysm bleeding or c erebrovascular dynamic- venous malformations rupture hemorrhage.3. Stroke patients or Merge the other parts of the tumor patients.4.Acute or chronic hepatitis patients or Severe liver function damage lead to blood coagulation dysfunction patients.5. Kidney disease ca use clotting abnormalities patients or Other diseases resulting in abn ormal Blood coagulation indexes 6.The late cerebral hernia. The c ontrol group : Choose the same time stay at this college or outpat ient medical center for physical examination and the results show n ormal and There is no family history of hypertension in immediate relatives. The number of the control group is forty. The age of the control group is between forty-seventy. There are 20 men and 20 women.Case group : In the case group,there is 30 men and 30 wome n,the age is between 40 and 70,the average age is 52.5±10.1. Cour se of the disease within 24 hours,the average course of the diseas e is 10.5±3 hours. Control group :three are 20 menand 20 women in this group. the age is between 42 and 66,the average age is 55.1±6.7. By Analysis of these data,the contorl group and the case group,there is no no statistical significance in terms of age an d gender composition(P<0.05).1) Grouping method: According to the illness severity, Accordi ng to the patients with GCS score on admission,The case group is divided into three groups:mild moderate severe.The number of the t hree groups are:GCS score in 3 ~ 8 points(severe) is 23.GCS scor e in 9 ~ 11points(moderate) is 27,GCS score in12 ~ 14points(mi ld) is 10. According to the prognosis condition to divide the grou p:Cases admitted to hospital after the treatment of 30 d day, and in30 days by ADL scores can be divided into four groups.ADL sco re of 0 to 20(Very serious)points and the number of cases is 10. ADL score of 25 to 45(severe)points and the number of cases is 17. ADL score of 50 to 70(moderate) points and the number of ca ses is 23. ADL score of 75 to 95(mild) points and the number of cases is 10.ADL score of 100(normal) points and the number of cases is 0.2) Detection method:On admission to take venous blood in patie nts with 4 ml,Venous blood centrifugal,put supernatant fluid in- 80 ℃refrigerator to cryopreservation.the control group is also taken4ml venous blood,and venous blood centrifugal,put supernatant fl uid in- 80 ℃refrigerator to cryopreservation.After all specimens were collected, By the enzyme-linked immunosorbent method(ELIS A),to test the expression level of the IL-6,TRAIL between the two groups.3) Statistical methods:All the data are processed by SPSS softw are analysis,the results are caculated by T test and correlation anal ysis method.Results:To compare the expression level of IL-6,TRAIL betwe en the control group and the case group,the expression level of the IL-6,TRAIL in the case group is significantly higher than the cont rol group(p<0.05). In the case group,we compare the three groups,we found that the lower the patients with GCS score,the expression levelof the IL-6,TRAIL is higher.Through correlation analysis,we fo und that p<0.05.It another word the expression level of the IL-6,T RAILand disease severity on admission to hospital show a positive correlation,which means the expression level of them shows a ne gativecorrelation GCS score on admission to hospital. To compare t he expression level of the them between ADL groups,the results have statistical significance(p<0.05).The higher the ADL score,the l ower the expression level of them,which means that the expression level of them Is negatively related with prognosis of patients.Conclusion: The TRAIL and its receptor and IL-6 may partici pate in a series of pathophysiological process of secondary brain inj ury in the HICH patients.The specific mechanism is unclear.The exp ression level of the TRAIL,IL-6 may be related to the seriousness of the patient’s condition and prognosis in patients.And we need m ore experiment to test if there is a correlation between the them. |
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