| Objective:1. To improve the knowledge of systemic lupus erythematosus (SLE) with relapse by studying clinical features of these patients.2. To discuss the value of laboratory tests and symptoms in predicting the relapse of SLE.3. To investigate the risk factors of SLE with relapse.Methods:Clinical data about the patients with SLE of relapse admitted to the Department of Rheumatology in our hospital from January 2012 to December 2014 were retrospectively analyzed with related literature reviewed. All patients fulfilled the 2009 Systemic lupus international collaborating clinics (SLICC) revised diagnostic criteria for the classification of SLE.Rusults:1. Demographic characteristics:Of the 947 participants,121 were men(12.8%),826 were women(87.2%). The mean (SD) age of the entire group was 34.14±13.3 years. Of the 198 patients with relapse,16 were men (8.1%),182 were women (91.9%), the mean (SD) age was 33.2±11.4 years. And the mean (SD) course of disease was 84.7±59.4 months. No significant differences in the sex ratio (P=0.095) and the age distribution (P=0.362) were observed between the 2 groups when tested.2. The frequency of relapse:A total of 199 episodes of relapse were recorded in 189 patients. Of the 189 patients with relapse,2 had 3 relapses,6 had 2 relapses, and the rest had 1 relapse.3. Possible reasons for relapse:Of the 199 relapses,93 (47.0%) with drug withdraw, 49(24.7%)with glucocorticosteroids withdraw,81(40.9%)with immunosuppressive agents withdraw,28(14.1%) with infection,13(6.6%) with fatigue,9(4.5%) with sun exposure,4(2.0%) with operation,no obvious reason was found for the rest 45(22.7%).4. Kaplan-Meier survival curve shows that course of disease and rash were related with relapse of SLE, p< 0.05,5. Cox multiple regression analysis showed that the coexistence of duration of 7 years, fever,rash, glucocorticoids withdraw and anti Sm antibody positive had effect on the recurrence of SLE. Conclusion:1. Sex ratio and the age distribution had no effects to relapse of SLE patients.2. Patients with shorter duration were more likely to relapse than those patients with longer duration.3. Patients without rash were more likely to relapse than those patients with rash4. Patients with drug withdraw were more likely to relapse. |
