Study On The Effect Of Weight Loss Of Healthy Overweight And Obese Adults In Urumqi Area

Objective: To study the effect of weight loss with high-protein and low GI dietary patterns among overweight / obese adults in Urumqi region, and to explore the effect of weight control with meal replacement interventions and their impact on glucose and lipid metabolism. Methods: Choose overweight / obese adults 711 cases subjects who through clinical and physical examination, met the inclusion and exclusion criteria, and signed the book in the First Affiliated Hospital of Xinjiang Medical University medical center, based on the random number table randomly assigned to education+dietary intervention group,simple education group and in the control group, 237 people in each group. In the six-month trial period, simple education group subjects received high-protein low glycemic index diet guidance, education+dietary intervention group subjects except for meals every day instead of two meals, control subjects without making any intervention.After 12 weeks, 24 weeks, respectively, collecting body composition indicators and laboratory index for statistical analysis. Results:(1)Average daily intake of energy, fat,carbohydrates, niacin, vitamin E, phosphorus, iron, selenium, copper, manganese are exceeded, the average daily intake of vegetables, fruits, fish are insufficient, and cereals,beans, oil exceed the recommended daily intake volume range, among overweight / obese adults in Urumqi region.(2)Subjects of education+dietary intervention group and simple education group overeating, eating out more, eating fast and other dietary behaviors were significantly improved compared with the intervention(P<0.05), and compared with the control group, the difference was statistically significance(P<0.05).(3) After 12 and 24 weeks intervention, transportation and exercise physical activity of subjects of education+dietary intervention group, increased compared with that before the intervention(P<0.05), 24 weeks after the intervention, subjects of education+dietary intervention group, compared with the control group, exercise physical activity, with astatistically significant(F=6.214, P<0.05).(4) Compared with 0 weeks, after 12, 24 weeks intervention, weight, BMI, WHR, body fat, body fat percentage, VFA of subjects of education+dietary intervention group was significantly lower(P<0.05), no significant changes in skeletal muscle(P>0.05); and the corresponding time points, weight, BMI,body fat, body fat percentage, VFA, skeletal muscle, and 24 weeks WHR of subjects of simple education group were significantly lower(P<0.05); these parameters of the control group were not significantly change(P>0.05). After 12 weeks intervention, the mean of weight, BMI, body fat, body fat percentage, VFA; 24 weeks after intervention,the mean of BMI, body fat, body fat percentage of subjects of education+dietary intervention group, compared with concurrent control group, simple education group, the difference was statistically significant(P<0.05). After 12 weeks intervention, the mean of skeletal muscle, and 24 weeks after intervention, the mean of VFA of subjects of simple education group, compared with control group in the same period, the difference was statistically significant(P<0.05).(5) Compared with 0 weeks, after 12 weeks intervention,the mean of TG, TC, LDL-C, and 24 weeks after the intervention, the mean of TG, TC,LDL-C, HDL-C of subjects of education+dietary intervention group, compare with simple education group and the control group, in the same period, the difference was statistically significant(P<0.05); after 12 weeks intervention, the mean of TC, 24 weeks after the intervention, the mean of TG, TC, LDL-C, compared with concurrent control group, the difference was statistically significant(P<0.05). After 12 weeks, 24 weeks intervention, the mean of ApoB of subjects of education+dietary intervention group and simple education group, compared with concurrent control group, the difference was statistically significant(P<0.05).(6) 12, 24 weeks after, AST, ALT, GGT, BUN, SCr,GLU, FINS, CRP of subjects of education+dietary intervention group, simple education group and control group, compared with 0 weeks, the difference was not statistically significant(P> 0.05). Conclusion:(1) Using meal replacement could help weight control,and may play a regulatory role in overweight / obese adults associated with abnormalities of lipid metabolism.(2) High-protein low GI diet mode has a significant effect on controlling body weight of overweight / obesity adults in Urumqi region, and it is worth promoting.