Etiological Features Of Cirrhosis In Patients Negative For HBsAg But Positive For Anti-HBs, Anti-HBe Or Anti-HBc

Objective:To investigate the features of the etiology of cirrhosis in patients negative for hepatitis B surface antigen (HBsAg), but positive for hepatitis B surface antibody(anti-HBs), hepatitis B e antibody (anti-HBe) or hepatitis B core antibody (anti-HBc).Methods:This was a retrospective case-control study.In patients with cirrhosis treated from January 2001 to December 2013 at the First Affiliated Hospital of Xinjiang Medical University were initially included.According to hepatitis B virus test results,patients who were HBsAg(-),but anti-HBs(+),anti-HBe(+)or anti-HBc(+)and those with cryptogenic cirrhosis were included into a study group and a control group,respectively.Demographic information and the incidence of metabolic syndrome and liver cancer were compared between the two groups.Results:Among the initially included 7012 in patients with cirrhosis,220(3.14%) were HBsAg negative but anti-HBs, anti-HBe or anti-HBc positive, and 147(2.10%) had cryptogenic cirrhosis. The mean age was significantly lower in the study group than in the control group(P< 0.05). The proportions of male patients(P< 0.05) and Han patients(P < 0.05) and the incidence of liver cancer(P< 0.05) were significantly higher, and the incidence of diabetes and hypertension(P< 0.05) was significantly lower in the study group than in the cryptogenic cirrhosis group.Conclusion:The two groups of patients had statistical differences in gender,age and the incidence of metabolic syndrome and liver cancer,suggesting that there are different etiological factors between HBsAg negative, with other HBV-associated positive cirrhosis and cryptogenic cirrhosis.