Incidence Of Pulmonary Thromboembolism In Patients With Nephritic Syndrome:a Meta-analysis

Objective:Thromboembolism is a common complication of nephrotic syndrome, but nearly more than 10 years of nephrotic syndrome in patients with renal vein thrombosis, pulmonary embolism incidence of a series of reports is still rare. According to the existing clinical study on incidence of pulmonary embolism of renal vein embolism caused by nephrotic syndrome.Methods:The system retrieves the PubMed database, Web of Science database, Chinese Biomedical Database, Wanfang database building a database to October 2014 on nephrotic syndrome, pulmonary embolism, renal vein thrombosis research papers and review various studies cited References to supplement. Application Review Manager 5.1 software for the retrieved data were consistent with the requirements of the combined benefits of homogeneity test and verify the amount.Results:Among 157 articles identified, according to inclusion criteria and exclusion criteria, a total of seven documents included in this study, all prospective study. The total sample size was 2324 cases of patients, including 237 cases of pulmonary embolism, renal vein thrombosis 213 cases. The incidence of pulmonary embolism rang from 1.5% to 41.3%, while reports the incidence of nephrotic syndrome with renal vein thrombosis rang from 1.4% to 42.3%. Meta-analysis included in the literature, there was no statistically significant difference in the incidence of renal vein embolism and pulmonary embolism, the combined effect size OR= 0.83,95% CI [0.43,1.61], the effect size test Z= 0.55, P= 0.58. Report the incidence of male patients with NS rang from 52.9% to 73%, meta-analysis showed that the combined incidence was 61%,95% CI [0.57,0.65], the effect size test Z=14.24, P<0.01.24-hour urinary albumin levels as a risk factor for thromboembolism have significant differences in the embolization group and non embolization group.Conclusion:The incidence of pulmonary embolism in thromboembolic complications of nephrotic syndrome is not lower than renal vein thrombosis, should attach importance to it. The level of plasma albumin and urinary albumin can be used as risk factors for venous thromboembolism.