Study Of Correlation Between IL-33 And Its Receptor ST2 In Non-alcoholic Fatty Liver Disease Patients With Obesity

Background Nonalcoholic fatty liver disease (NAFLD) is a clinical and pathological syndrome. The main feature is steatosis of hepatocytes induced by pathologic factors except alcohol and other known factors. NAFLD spectrum includes non-alcoholic steatohepatitis (NASH), nonalcoholic fatty liver (NAFL) and related cirrhosis and hepatocellular carcinoma. In recent years, NAFLD prevalence was increasing with the improvement of people’s living standard. NAFLD has become the second largest disease which is second only to the viral liver disease. It has become one of the important global public health problem in this century, and thus people has paid more and more attention to the NAFLD.Objective The levels of serum IL-33 and its receptor ST2 were measured in the NAFLD patients with obesity and the NAFLD patients without obesity. The correlation was analyzed between the levels of IL-33 and its receptor ST2 with NAFLD patients with obesity.Methods 80 cases of patients with NAFLD who meet the requirements were chosen.52 cases of them were the NAFLD patients with obesity, the other 28 were the NAFLD patients without obesity. The weight, height, hip circumference and waist circumference were measured respectively in the NAFLD patients with obesity and the NAFLD patients without obesity. The levels of serum triglyceride (TG), total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high density lipoprotein cholesterol (HDL-C), aspartate aminotransferase (AST) and alanine aminotransferase concentrations (ALT) were measured. The levels of serum IL-33 and its receptor ST2 were assayed by enzyme-linked immunosorbent assay (ELISA). The results were analyzed by SPSS 16.0 software wrap, and a P value of less than 0.05 was considered to be statistically significant.Results The BMI, waist circumference, hip circumference, waist-hip ratio of the NAFLD patients with obesity were higher than that of the NAFLD patients without obesity (P <0.05). The levels of serum triglycerides and low-density lipoprotein cholesterol were higher than that of the patients without obesity(P<0.05). The levels of serum total cholesterol, high-density lipoprotein cholesterol, aspartate aminotransferase and alanine aminotransferase between the two groups showed no significant difference. The levels of serum IL-33 and ST2 of the NAFLD patients with obesity were higher than the patients without obesity (P<0.05). The level of serum IL-33 was positively correlated with ST2 level (r=0.735, P<0.05).Conclusions The levels of IL-33 and its receptor ST2 in serum were positively correlated with the NAFLD patients with obesity.