Study On The Differences Of The Related Inflammatory Factors And Tcm Constitutions Between Patients With "fast" And "slow" Development Of COPD Before And After A Year

Objective: To observe the changes of the related inflammatory factors and Traditional Chinese Medicine(TCM) constitutions between patients with "fast" and "slow" development of chronic obstructive pulmonary disease(COPD) before and after one year so as to know the differences in progression of the disease between the two groups of patients.Methods:13 cases of fast development of COPD and 44 cases of slow development of COPD were collected from Department of Respiratory, the Affiliated Traditional Chinese Medical Hospital of Xinjiang Medical University from October 2012 to October 2013. ELISA was used to detect the changes of lung function, erum interleukin-2(IL-2) levels, interleukin-4(IL-4) levels, mor necrosis factor-a(TNF-a), Interferon-γ(IFN-γ). Questionnaire was issued to determine the TCM Constitutions scores of breathing difficulties to index(m MRC) and COPD assessment test(CAT). Results:IL-4, MRC, CAT scores in patients with "fast" COPD development decreased significantly(P<0.05) than those one year ago; FEV1%pre, FEV1/FVC, TNF-a, CAT scores in patients with "slow" COPD development were significantly lower(P<0.05) compared with those one year ago; there were statistical differences in FEV1%pre, MRC, CAT scores between "fast" and "slow" COPD development groups. Conclusion:Serum IL- 4 and TNF- a were involved in the occurrence and progression of COPD, and the dynamic tests of these levels can be used as reference indicators for the progression of COPD. In the meanwhile, the differences in expression levels of inflammatory factor can result in differences in progression of COPD. FEV1 % pre, CAT scores, m MRC are effective and reliable methods in assessing the progression of COPD and patients’ life quality.