Meta-analysis Of Diabetes Mellitus And Risk Of Incidence And Mortality On Endometrial Cancer

Objective:To investigate the association between diabetes mellitus (DM) and the incidence and disease-specific mortality of endometrial cancer (EC). Methods:A meta-analysis was conducted according to guideline set forth by Meta-analysis of observational studies in CBMdisc, Wanfang databased, CNKI, VIP in Chinese, OVID, PUBMED, EMBASE, and MEDLINE in English. Quality assessment was given based on The Newcastle-Ottawa Scale. Test for heterogeneity was assessed by Chi-square test of the Cochrane Q statistics and I2 test, test level was 0.05, then choose a fixed-effects model or random-effects model. Publication bias was assessed by visual examination of a funnel plot. Extracting relevant information to collected and Calculated through STATA12 and Microsoft Excel software. Results:23 cohort studies entered this Meta-analysis review. The incidence of endometrial cancer in diabetic patients the pooled relative risk RR was 1.68, [95%CI(1.36,1.57), P=0.145] Compare with non-diabetic patients, and the incidence of the pooled hazard ratio HR was 1.46, [95%CI(1.36,1.57), P=0.053]. The mortality of endometrial cancer in diabetic patients the pooled relative risk RR was 1.47, [95%CI (1.06, 2.04), P=0.44]. Compare with non-diabetic patients, the pooled standardized mortality ratio SMR was 1.34, [95% CI (0.79,2.27), P=0.241]. Subgroup analyses were conducted by study design, year of publication, geographical region, type of DM, and adjustments for some variables. It was consistently observed in each subgroup that DM increased EC incidence. Conclusion:DM as a risk increase the incidence and disease-specific mortality of EC.