The Expression And Clinical Significance Of Prox1 Protein In Primary Hepatic Carcinoma

Objective: To investigate the expression of Prox1 protein in primary hepatic carcinoma.Methods: Selected 54 cases of PHC tissue and cancer adjacent in the First Affiliated Hospital of Soochow University from March 2014 to December 2014. All the cases were surgical resection and not received chemotherapy before surgery. They were pathologically confirmed and had complete clinical and pathological data. Collected 13 cases in the same period receiving surgery due to other liver diseases as a normal control group. Immunohistochemistry was used to detect the expression of Prox1 protein,which was distributed by PHC tissues, adjacent tissues and normal liver tissues.Results: 1) Prox1 protein in PHC tissues, adjacent tissues and normal liver tissues were expressed, but PHC tissues(2.79 ± 3.09) and adjacent tissues(4.42 ± 3.59) was lower than that in normal liver tissues(5.30 ± 2.95). There was a statistically significant difference(P <0.05) between the three groups, which pairwise comparison, PHC tissues and adjacent tissues(P = 0.039), PHC tissues and normal tissues(P = 0.039), the differences were statistically significant(P <0.05). PHC tissues and adjacent tissues(P = 0.735) had no statistical difference.2) Differences of Prox1 expression of varying degrees of differentiation(F = 86.13, P <0.01) in liver tissue were statistically significant. Correlation analysis showed that, with the increase of the degree of differentiation of PHC, the relative amount of protein expression increased that Proxl protein expression and PHC differentiation(r = 0.930, P <0.01) were positively correlated.3) The expression of Prox1 protein in Hepatocellular carcinoma(P = 0.220) and Cholangiocarcinoma(P = 0.911) had no statistical significance.4) Prox1 protein expression was irrelevant with Hepatitis B. P values were 0.863,0.621,0.789, which respectively represent the expression in PHC tissues, adjacent tissues and normal tissues. They were no significant differences.Conclusion: PHC Prox1 protein is highly expressed in normal liver tissue, while Prox1 expression is related with tumor differentiation, the higher the degree of differentiation, the higher expression. Prox1 may be associated with the occurrence and development of PHC, but whether it is a suppressor gene still need further study.