Evaluation Of ¹²³I-FP-CIT SPECT In Dementia With Lewy Bodies: A Meta-analysis

Aim To systematically value the diagnostic accuracy of ¹²³I-FP-CIT（Da TSCAN） in dementia with Lewy bodies.Methods Relevant literature was searched in the Pub Med, Embase, Cochrane, CBM and CNKI databases, and their quality was valued by QUADAS. The diagnostics sensitivity, specificity, positive likelihood ratio（PLR）, negative likelihood ratio（NLR） and heterogeneity were pooled by Meta Disc software. Summary receiver-operating characteristic（SROC） curve was constructed. Stata statistical software（version 10.0） was used to assess the publication bias with Harbord-Egger.Results Five literature were included. ¹²³I-FP-CIT（Da TSCAN） could be used to identify dementia with Lewy bodies with overall sensitivity, specificity, PLR, NLR, and AUC of 0.80（95%CI: 0.73-0.86）, 0.93（95%CI: 0.89-0.95）, 10.10（95%CI: 6.71-15.20）,0.22（95%CI: 0.12-0.39）, 0.9671, respectively. There was significant heterogeneity of pooled value of sensitivity, while no significant heterogeneity was observed in other items. Moreover there was no significant publication bias found（P=0.089） accessed with Harbord-Egger indictor test.Conclusion¹²³I-FP-CIT（Da TSCAN） is valuable for diagnosis in dementia with Lewy bodies.