| Objective:Erectile dysfunction (ED) shows the penis cannot achieve and (or) maintain adequate erections to obtain satisfactory sexual life (sex).It is the most common sexual dysfunction disease. Divided into mild,moderate and severe. With the increase of age, the incidence of severe ED showed a rising trend. Some scholars believe that ED may be a sign of atherosclerosis. Thyroid is one of the most important endocrine glands, synthesis and release thyroid hormone. Hyperthyroidism is due to thyroid hormone is synthesissd and released in excess, Causes the body’s metabolism hyperthyroidism and sympathetic excitement. Expressed as heart palpitations, sweating, increasing food intake and diarrhea and weight loss.It is a kind of common endocrine disease. The main causes include diffuse toxic goiter (Graves disease), toxic multinodular goiter and thyroid independent high functional adenoma (Plummer disease) etc. It has found that severe hyperthyroidism may cause arteriosclerosis, heart failure, cerebral vascular accident by injured of vascular endothelial cells. Injured of vascular endothelial is considered to be the main pathogenesis of ED. In this study, compared the differences of vascular endothelial and erectile function merge between the group of ED with hyperthyroidism and normal patients, investigated the influence of hyperthyroidism on ED patients with vascular endothelium, and provide a theoretical basis for the future clinical better treatment of ED.Methods::Selected 81 patients with ED and hyperthyroidism as the test group. The simple hyperthyroidism group as group A for 24 cases, the ED group as group B for 46 cases, the ED with hyperthyroidism group as group C for 11 cases. The normal population at the same period as group D (control group) 55 cases. (1) statisticed the age, BMI, waist hip ratio of all subjects, and 8p.m.measurement of systolic and diastolic pressure. At the same time drawed elbow vein blood 5 ml centrifuge to measure the total testosterone. (2) International index of erectile function (the IIEF-5 standards), A total of 25 points, more than 22 points, no ED, less than 22 points determined to be ED,57 for severe ED and 8～11 for moderate ED,12-21 were divided into mild ED. (3) FMD detection method:used two-dimensional ultrasound to measurement the right upper limb brachial artery diameter (DO), after reactive hyperemia test,determinate the inner diameter of the right upper limb brachial artery of (D1), FMD=[(D1-D0)/D0]*100%. FMD criteria:FMD is greater than or equal to 10% for the endothelial function in normal, FMD is less than 10% damage to vascular endothelial function.Using SPSS 17 analysis software, the deference of IIEF-5 score and FMD values between each group were analysis by independent samples t test, data is represented inx±s, other influencing factors among many groups were subjected to analysis of variance, P< 0.05 indicates a statistically significant difference.Result:1 compared with the age, BMI, waist hip ratio, systolic blood pressure, diastolic blood pressure, total testosterone:between the test and control group, among three test groups with no statistically significant differences, P>0.05.2 IIEF-5 score comparison:group B, C had significance statistical difference compared with group D, P<0.05, the IIEF-5 score of group B and group C were lower than those of group D; group A compared with D group had no significant difference, P>0.05. Among group A, B, C, It had significant difference, P<0.05, in which group C was the lowest score, the second was group B.Comparison of FMD:the A, B, C compared with the control group had significant difference, P<0.05, the values of FMD in A, B, C were lower than group D; the A, B, C between the three groups had significance statistical differences, P<0.05, the C had the lowest FMD value, the B was the second, the A was the highest.Conclusion:In this study, the age, height, waist circumference, hip circumference, testosterone and blood pressure between the test and the control group had no significant difference,so that all selected objects had comparability. Compared with group B, C and D, the IIEF-5 score had a significant difference, the B,C were lower than those of group D. the A, B, C had statistical significance differences, the IIEF-5 score of group C was the lowest, the second B, this was speculated that the thyroid function may affect the erectile function; among A, B, C and D, FMD value had significant difference, the values of A, B, C groups were lower than D, between groups A, B, C it had significance statistical difference in the value of FMD, in which the C group had the lowest FMD value, the second B, group A was the highest, Presumably thyroid function may impair the vascular endothelial function and effect the erectile function. |
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