The Correlation Of HIF-1α,MACC1 And FOXO4 In Gastric Carcinoma Pathology And Prognosis

Objective To explore significance and impact of HIF-1α, MACC1 and FOXO4 in gastric carcinoma and clinical pathological characteristics and prognosis.Methods 110 samples diagnosed as gastric carcinoma and 46 samples diagnosed as pericarcinomatous tissue which was 5cm far away from cancer were collected in first affiliated hospital of Anhui medical university from December 2006 to May 2008. Immunohistochemical staining was performed in these samples to detect the expressions of HIF-1?, MACC1 and FOXO4. And the correlation between development of gastric carcinoma and expressions of HIF-1?, MACC1 and FOXO4 was analyzed with the help of patients’ messages. Kaplan-Meier method and Cox regression were used to analyze patients’ 5 years survival rate and the factors.Results The expression levels of HIF-1?(P<0.001) and MACC1(P<0.001) in gastric carcinoma tissues were significantly higher than that in pericarcinomatous tissues, however the expression level of FOXO4(P<0.001) was significantly decreased in gastric carcinoma tissues. Statistical analysis revealed that the expressions of HIF-1? and MACC1 were apparently increased with lower degree of cell differentiation, greater degree of tumor infiltration, accompanied with lymph node metastasis and higher TNM scores, but lowered expression of FOXO4 factor. There were significant correlations between expressions of the three factors in gastric carcinoma. expressions of HIF-1?, MACC1 and FOXO4 have an apparent influence on the patients’ 5-year survival rate. And they are independent factors on the prognosis of gastric carcinoma.Conclusion1) HIF-1? and MACC1 are expressed highly in gastric carcinoma while FOXO4 is expressed lowly And there are significant correlations between expressions of the three factors in gastric carcinoma.2)HIF-1α、MACC1、FOXO4 are associated with the degree of cell differentiation, tumor infiltration, lymph node metastasis, TNM scores and prognosis of patients.3)HIF-1?, MACC1 and FOXO4 are likely to be the independent prognostic predictors for progression and patient survival of gastric carcinoma.