Analysis Of The Correlation Between Indications For Cordocentesis And The Detection Rate Of Fetal Chromosome Abnormalities

Objective:To determine the value of indications for invasive prenatal diagnosis and the clinical significance of cordocentesis.Methods:In a retrospective study, data were assessed from singleton-pregnancy women with indications who underwent cordocentesis in the second and third trimester at the laboratory of Shandong Provincial Hospital, from January 1,2006 to December 31, 2014. The cordocentesis records and medical data of all women were analyzed statistically.Results:During the 9-year period, cordocentesis was performed in 324 cases receiving pretest genetic counseling and informed consent in the second and third trimester. The culture success rate was 95.68%. Normal karyotype was found in 227 cases (73.23%), chromosome polymorphism in 15 cases(4.84%) and abnormal karyotype in 68 cases(21.94%). There were 51 cases with chromosome number abnormalities, 16 cases with chromosome structure abnormalities and 1 case with true hermaphroditism. Trisomy 21 was the most prevalent chromosomal abnormality (38.24%,26/68). In abnormal ultrasound finding group, screening high risk group, abnormal amniotic fluid chromosome group, abnormal non-invasive examination results group, abnormal history of reproduction or family history group, parents with chromosomal abnormalities group, with more than two indications at the same time group, the abnormal karyotype detection rate was 15.00%.19.35%. 51.35%.54.17%.20.00%.66.67% and 39.33% respectively, there was significant difference between the groups(P<0.05), the chromosome polymorphism detection rate was 4.44%.8.06%.5.41%.0.0.0 and 1.12% respectively, there was no significant difference between the groups(P>0.05). There was no significant difference of abnormal karyotype detection rate or chromosome polymorphism detection rate among all kinds of abnormal ultrasound findings(P> 0.05). Abnormal ultrasound findings along with advanced age or other indications would increase the detection rate of fetal chromosomal abnormalities.Conclusions:There was a relationship between the detection rate of chromosome abnormalities and the prenatal diagnosis indications. The abnormal karyotype detection rate in abnormal ultrasound finding group and screening high risk group was relatively low. Abnormal ultrasound findings along with advanced age or other indications would increase the detection rate of fetal chromosomal abnormalities. Prenatal diagnosis was an effective method to reduce the birthrate of child with chromosome defects. It should be widely promoted so that more families benefited.