Significance Of Ultrasound In The Diagnosis And Treatment Of Rheumatoid Arthritis

Discussion of articular ultrasonography in early diagnosis and treatment of rheumatoid arthritis in guiding significance.Collected 80 cases of the activities of the rheumatoid arthritis (RA) patients as the experimental group.20 healthy volunteers as control group, for the involvement of the heavier side metacarpophalangeal in the experimental group,the proximal interphalangeal joint of ultrasound scan,detection of synovial joints maximum thickness,the blood flow grading and effusion thickness,At the same time,take the DAS28 score of the experimental group(The 28 joint disease activity score) and perfect the anti cyclic citrullinated peptide antibody(anti-cyclic chlorinated peptide antibodies Anti CCP antibody)、Erythrocyte sedimentation rate(ESR)、C reactive protein (CRP) and Rheumatoid factor (RF) laboratory examination. The experimental group was treated with methotrexate (MTX) (10mg weekly oral) Merge with Leflunomide Tablets(LEF)(Daily oral lOmg) Specification for 3 months, Respectively of articular ultrasonography in patients of each group before and after treatment、DAS28 score and the comparison of serum and immunological detection. In 20 healthy subjects were bilateral metacarpophalangeak The proximal interphalangeal joint ultrasonography and taking a measurement of maximum thickness of synovial join^ the blood flow grading and effusion thickness. All data are used SPSS 17.0 Statistical software for storage and processing. In the statistical analysis, The chi square test was used for analysis and processing of count data processing. In the light of measurement data, In the first step, The experimental group and the control group using two independent samples T test or approximate T test analysis and processing, the second step,single factor correlation analysis using Pearson correlation analysis method for measurement data, By using Spearman rank correlation test for count data, The level of test a=0.05, there were statistically significant differences in P<0.05. The third step, Compared with the paired samples T test before and after treatment, and by the average-and standard deviation (x±s) to express.The ultrasound group RA lesions of synovial membrane thickness of synovial thickening compared with control group, The experimental group joint synovial thickness ultrasonic classification of weakly correlated with ESR, (r=0.233, P=0.037),there is no correlation with RF, (r=-0.058, P=0.608), Anti CCP antibody and weak correlation (r=0.107, P=0.346), Ultrasonic hyperplasia of synovial blood flow rating is positive correlation with ESR, (r=0.645, P=0.001),No correlation with RFCr=-0.125, P=0.627), Positive correlation with anti CCP antibody (r=0.196, P=0.082), Positive correlation with CRP (r=0.665, P=0.001), With the score of ESR is positively related to ultrasonic joint effusion (r=0.536, P=0.001), No correlation with RF (r=-0.026, P=0.817), Weakly correlated with CCP (r=0.049, P=0.667), Weakly correlated with CRP (r=0.385, P=0.001), about the experimental group Ultrasound synovial membrane thickness,Correlation analysis did not show significant difference between before and after RA treatment,but there are Correlation analysis of differences between Ultrasonic joint synovial blood flow rating-. Joint effusion n Markers of inflammation (ESR、CRP) and Anti CCP antibody before and after treatment.Joint ultrasonography of RA metacarpophalangeal, The proximal interphalangeal joint synovial lesions detection has a certain value. There is guiding significance between early diagnosis of RA、monitoring of RA disease activity and Monitor the effect.