A Preliminary Exploration Of The Formation Of Cerebral Aneurysms With Symptoms Of Traditional Chinese Medicine Study

ObjectiveThis study, based on our preliminary design of a new type of hemodynamic perfect in aneurysm model of rats, and using the model of cerebral aneurysm into tumor factors are discussed. This study intends to use the new type of aneurysm model rats to research brain aneurysm formation and development process of the pathological changes of the blood vessel walls。At the same time, through collecting the clinical of traditional Chinese medicine (TCM) in patients with symptomatic cerebral aneurysms, Research on This relationship bettwen brain aneurysm patients disease and TCM symptoms distribution correlation.MethodsThe subject is divided into two parts as a whole. The first part is the animal experiment, making improved aneurysm model rats as experimental group, using means of pathological detectionto to carry on the preliminary assessment, and comparing with the control group. Observe each animal’s brain aneurysm rate, Compare the situation of pathological changes in each animal blood vessel walls, to record each rat mortality. The second part is clinical retrospective study, review all the patients with (Confirmed by DSA) from Neurosurgery department of Guangdong hospital of TCM,In January 2013 December 2014。Statistics the symptoms of stroke in patients with type, Try to analysisThe relationship between the incidence of aneurysm and TCM symptoms.ResultsThe results of the first part of the experimental:control group and experimental group rats mortality rates were 0% and 20% respectively。The mean arterial pressure of the control team has no obvious fluctuation, The mean arterial pressure of improved group after 1,2,3 months were gradually increasingo Through the asana microscope, After 3 months, the rate of control group into tumor is 0%(0/15), the rate of the new brain aneurysm model group into tumor is 33%(4/12).by HE dyed pathological, we can see the pipe diameter and thickness of both Hashimoto model and improved model rats are increased, the results of the second part retrospective study:By The case investigation of 28 cases patients with cerebral aneurysms see a doctor in our hospital In January 2013-December 2014, we analysis the TCM syndrome distribution, preliminary summary aneurysm TCM etiology and pathogenesis of the disease。Results showed that patients with cerebral aneurysm is more of TCM syndrome are heat syndrome, phlegm syndrome, blood stasis, and less TCM syndromeis are deficiency of certificate.Conelusion1. the improved model can effectively produce brain aneurysm, it can be used for the study of aneurysms; Chronic inflammatory response associated with MCP-1 is closely related with the formation of the aneurysm.2. The TCM symptoms of patients with cerebral aneurysms were retrospectivelyanalyzed, the results suggest that wind, heat, phlegm turbidity and blood stasis combined action, is a key to TCM pathogenesis of patients with cerebral aneurysms. phlegm turbidity’s decline after operation is not obvious, it results suggest that it is a key to the development of the aneurysm.