| ObjectiveThis study was to investigate whether general population long-term exposured to pentachlorophenol contaminated area would associate with the risk of cancer. The data of pentachlorophenol was from raw drinking water.MethodsThe cancer cases data of a county in Maanshan city from 2011 to June 2014 were used by searching new rural cooperative medical system and urban employees’ medical system. Cancer incidence rate, standardized incidence rate, constituent ratio and age-specific incidence rate was calculated, based on the demographic data and cancer type. The study area was divided into three exposure categories(high exposure category, medium exposure category and low exposure category), based on quartiles of PCP levels in water source. Cancer incidence rate and age-standardized rate of the three exposure categories was respectively calculated. Compared with the low exposure category(reference), the standardized incidence ratios(SRR) with 95% confidence intervals(CI) of medium and high categories were also calculated.Results3836 cancer incident cases were totally reported from 2011 to June 2014, and the average crude cancer incidence rate was 175.42 per 100000, the average age-standardized rate was 119.57 per 100 000. The average crude cancer incidence ratewas 208.51 per 100000, the average age-standardized rate was 170.96 per 100000 for male. For female, the average age-standardized rate was 119.57 per 100000. The average crude cancer incidence rate was 140.42 per 100000, the average age-standardized rate was 122.25 per 100000. The cancer incidence in male was higher than that in female with SRR=1.49, 95%CI=1.47-1.50. Incidence of breast cancer, thyroid cancer, gallbladder and other carcinoma and brain and nervous system cancer in female was higher than that in male. The top ten cancer incidences of local population were gastric cancer, lung cancer, colorectal cancer, esophageal cancer, liver cancer, breast cancer, pancreatic cancer, thyroid cancer, nasopharyngeal carcinoma and bladder cancer. The age of incidence for male and female was mainly over 50 years old, which accounted for 79.39% of all cancers.PCP concentration of samples was measured by gas chromatography-tandem mass spectrometry. The minimum detectability was 1 ng/L. The recoveries of standard addition were 91.9-109%, and the relative standard deviations were 2.1-4.7%. The total water samples were 25, and PCP was detected in every sample with ranging from 3.91 to 68.46ng/L.The average crude cancer incidence rate was 121.46 per 100000, the average age-standardized rate was 82.14 per 100000 in low expose category. The average crude cancer incidence rate was 191.76 per 100000, the average age-standardized rate was 130.93 per 100000 in medium exposure category. The average crude cancer incidence rate was 223.81 per 100000, the average age-standardized rate was 153.09 per 100000 in high exposure category. Compared with the low exposure category(reference), the SRR of medium exposure category was 1.59 with 95%CI: 1.58-1.60, and high exposure category was 1.84 with 95%CI: 1.83-1.85. Compared with reference, most SRR of cancers increased with the increase of PCP level. Malignant lymphoma and leukemia increased significantly in high exposure category. Compared with reference, most SRRof cancers increased with the increase of PCP level in each age group. Malignant lymphoma, leukemia, thyroid cancer and ovarian cancer increased significantly in high exposure category.ConclusionsIncidence of gastric cancer was highest in the county. The cancer incidence in male was higher than that in female. Middle-aged and old people have become the high risk group of cancer, so the healthcare of them and prevention of cancer should be reinforced. With the increase of PCP level, most incidences of cancers increased in the county. Malignant lymphoma, leukemia, thyroid cancer and ovarian cancer increased significantly in high exposure category. PCP exposure might associate with the malignant lymphoma, leukemia, thyroid cancer and ovarian cancer. This research was an ecological study, further researches are needed to confirm our results. |
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