Correlation Study Between Functional Polymorphism Of BDNF RS6265 And Sporadic Alzheimer’s Disease

Objective To explore the relationship between functional polymorphism of BDNF(brain-erived neurotrophic factor) rs6265 and sporadic Alzheimer’s disease(SAD).Methods Selecting 58 cases of SAD(SAD group) and 52 health old person(control group) as research subjects. Then the genotyped was detected via polymerase chain reaction-restriction fragment length polymorphism and serum levels of BDNF detected by Enzyme-linked Immunosorbent Assay in all cases.Results There was significantly difference in the distributions of alleles(x2=6.0595, P=0.013) and genotypes(x2=6.0826, P=0.0478) between the case of SAD group and control group,and the serum levels of BDNF were lowest for case of AA genotypes in SAD[(14.32±4.21) ng/ml, F=7.2545, P=0.0016].Conclusion The functional polymorphism of BDNF gene(rs6265) correlated with pathogenesis of SAD and affects the expression of BDNF in serum.