| Abjective:(1)Screening the Risk factors for the first occurrence of patients with acute ischemic stroke.(2)Study on the effect of Zhilong Huoxue tongyu Capsule on the first pass of acute ischemic stroke and cerebral vascular function score less than 75 points with the prognosis of patients. Methods: From January 1, 2013 to January 1, 2014 in our hospital during the period, 200 cases of acute stroke patients and 200 cases of physical examination center without the stroke analysising the correlation and risk factors. The cerebral vascular function detection ≤ 75 points of ischemic stroke in 111 patients, were randomly divided into experimental group and control group. Their correlation by using person correlation analysis of cerebral vascular function and dysfunction, and quality of life, life ability score and Creaction protein. Results:(1) Combined with the history of hypertension(42.5% vs 9.5%), the history of coronary heart disease(11.5% vs 2.0%) 、 the history of diabetes(18.0% vs 6.0%) were significantly higher in the observation group than that of control group, the difference was significant. Patients in the observation group of CRP, D-dimer, Hcy, triglyceride and LDL-C content was obviously higher than that of the control group, significant difference(P<0.05).(2) History of hypertension(OR: 7.04, 95% CI: 4.06- 12.20, P<0.001), the history of coronary heart disease(OR: 6.37, 95% CI: 2.16-18.77, P=0.012), the history of diabetes mellitus(OR: 3.44, 95% CI: 1.73- 6.83, P=0.026), Hs-CRP(OR: 1.03, 95% CI: 1.01-1.10, P=0.005), the D-dimer(OR: 1.06, 95% CI: 1.02-1.14, P=0.009) and Hcy(OR: 1.04, 95% CI: 1.01-1.09, P=0.041) are acute ischemic stroke risk factors.(3) The Zhilong group of average heart rate(P=0.004), total cholesterol(TC)(P<0.001), the useing of statins in prehospital(P=0.041) were higher than of control group, having statistical difference; the conventional group ACEI/ARB use rate is higher than the Zhilong group, having statistical difference(P=0.037).(4) The Zhilong group and the conventional group were followed up to six monthes, the conventional group was significantly higher than the Zhilong group with neurological dysfunction score(5.67±1.55 vs 4.24±1.12, having statistical difference(P<0.001). The Zhilong group with cerebral vascular function score(88±13 vs 79±20, P=0.006) and life quality score(220.95±39.60 vs 200.13±34.95, P=0.004) was significantly higher than the conventional group,having statistical difference. The Zhilong group of proportion with adverse even(7.3% vs 28.6%, P=0.004) and stroke recurrence(5.5% vs 21.4%, P=0.014) were significantly lower than that the conventional group, having significant difference.(5) The Zhilong group before intervention and follow-up function of cerebral vascular function score six monthes(26±8 vs 12±5,P<0.001), nerve dysfunction(-(5.4±2.1) vs –(3.6±1.6),P<0.001), quality of life(42±19 vs 33±12,P=0.004) and life ability score(59±18 vs 48±14,P<0.001) raise/low value are higher than the conventional group, with significant difference.(6) The age(HR: 1.01, 95% CI:1.00-1.04, P=0.031), history of hypertension(HR: 2.12, 95% CI: 1.67-4.17, P=0.001), coronary heart disease(HR: 2.91, 95% CI: 1.34-6.28, P=0.036), Hs-CRP(HR: 1.08, 95% CI: 1.02-1.26, P=0.003), cerebral vascular function score(HR: 0.94, 95% CI: 0.81-0.98, P=0.015) are inpendent risk factors of patients with acute ischemic stroke incidence of adverse events. The capsule(HR: 0.41, 95% CI: 0.18-0.91, P=0.036) is a protective factor for patients with acute ischemic stroke event.(7) There was a negative correlation between the scores of cerebral vascular function and neuralfunction defect score and Hs-CPR score and quality of life; life ability score were positively correlated. The neural function defect score and the score of quality of life, life ability scorenegatively correlated and positively correlated with Hs-CRP. The score of life quality and life ability score were positively correlated. |
PDF Full Text Request