Allogenic Acellular Extracellular Matrix Repairs High Anal Fistula

Objective:To observe the clinical effect of acellular extracellular matrix in the treatment of high anal fistula, and to explore a minimally invasive treatment for high anal fistula.Methods:Totally 100 cases of high anal fistula were randomly divided into treatment group and control group,50 cases in each group. Treatment group were treated with acellular extracellular matrix, and control group were treated with traditional low incision with high thread-drawing. Then, we observed and compared the operation time, postoperative pain score (visual analog scale score), postoperative pain duration, anal incontinence severity score (Wexner score), the postoperative complications,wound healing time, the length of time,one-stage success rate, cure rate, recurrence rate.Results:Compared with the control group, the treatment group showed lower scores in the operation time, visual analog scale score, postoperative pain duration, anal incontinence severity score (Wexner score),wound healing time, the length of time (P< 0.05), but higher scores in one-stage success rate and cure rate (P< 0.05). There was no difference in the recurrence rate and the postoperative complications between the two groups.Conclusion:These findings indicate that the acellular extracellular matrix for treatment of high anal fistula exhibits small trauma, quick recovery, short course of treatment, high cure rate and has no damage to the anal function and appearance.