| Objective:To observe the change on patients with stable angina in exercise tolerance,angina pectoris,and quality of life before and after treatment, evaluate the effect and security of Trimetazidine on improving exercise tolerance, relieving angina pectoris, improving the patient’ s quality of life.Methods:40 cases of stable angina according to the diagnosis criterion were randomly divided into two groups:experimental group and control group. Patients in the experimental group were administrated with conventional medicine and Trimetazidine,and the dosage is three times a day and each time 20mg. The control group were administrated with conventional medicine.The treatment lasted 8 weeks. To observe the change on exercise tolerance, the frequency of angina pectoris and the distance of thirty minutes walk.Results:The comparison of angina pectoris:The attack frequency and duration,the degree of pain were decreased in two groups on different time points after treatment.There were also significant differences between the two groups after 8 weeks in the attack frequency and duration(P<0.05), and the experimental group is better than the control group. The comparison of exercise tolerance indicators:In the total exercise duration, after 8 weeks of treatment, two groups of patients compared with before treatment were increased, the difference was statistically significant(P< 0.05).Comparing the experimental group with the control one, the increases in the total exercise duration had statistically significant(P<0.05),and experimental group was better than the control group.Conclusion:The study indicates that Trimetazidine can improve exercise tolerance of patients with stable angina, increase distance of thirty minutes walk, and decrease frequency of angina pectoris. |
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