Pathogens Distribution And Drug Resistance Analysis Of Patients With Acute Exacerbation Of Chronic Obstructive Pulmonary Disease

Background Chronic obstructive pulmonary disease(COPD) is one of the most common respiratory diseases worldwide, because of its incompletely reversible airflow obstruction and progression, the decrease of pulmonary function,the labor and life quality of patients are severely impaired, which cause huge social economic and medical burden.It is estimated that COPD affect more than 63 million people in world-wide[1],and will be the fifth disease financil burden and the third cause of death in the world by 2020.There are nearly 40 million people suffering from the disease in China.Acute exacerbation of chronic obstructive pulmonary disease(AECOPD) is an important process in COPD, and is an important reason that lead to continual hospitalization and death, which bring serious economic burden to the society and families[2].Therefore, aggressive treatment of AECOPD is crucial to slow down COPD and reduce the mortality.The purpose of this retrospective analysis is to understand the pathogenic bacteria distribution and drug resistance in patients with AECOPD of Anhui in six years.Objective To understand the pathogenic bacteria distribution and drug resistance in patients with AECOPD.Methods The retrospective analysis was performed in the sputum culturs and drug resistance results of 740 patients with AECOPD.Results The positive rate of bacterial infection was 39.1%.Among them, gram-negative bacteria was 196 strains(62.4%), gram-positive bacteria 21 strains(6.7%), and fungi 97 strains(30.9%).The main kinds of gram-negative bacteria were Pseudomonas aeruginasa, Acinetobacter baumannii,Klebsiella pneumoniae,Stenotrophomonas maltophilia and Escherichiacoli. Staphylococcus haemolyticus, Streptococcus pneumoniae and Staphylococcus aureus were the most frequent gram-positive bacteria.The major fungi was Candida albicans.Gram-negative bacteria showed highly resistance to the thirdgeneration cephalosporins,penicillins, moderately resistance to aminoglycosides,lowly resistance to imipenem.Gram-positive bacteria were resistant to many kinds of antibiotics, but they were responsive to linezolid and vancomycin.Fungi showed highly sensitivity to antifungal agents.Conclusion Bacteria infections were an important trigger for COPD exacerbations.The pathogens of AECOPD mainly were gram-negative bacteria with a highly drug resistance rate. To monitor pathogenic bacteria is conducive to master the pathogens distribution, drug resistance and provide the basis of rational use of antibiotics,which can slow down the emergence and spread of resistant bacteria.