The Effect Observation Of Vaginally Administered Finn On Intrauterine Adhesion

Objective: 15 intrauterine adhesion(IUA) acceptted vaginally administered Finn for 12 weeks after transcervical resection of adhesion(TCRA).To evaluate the effectiveness and security of vaginally administered Finn on Intrauterine Adhesion through menstrual quantity, endometrial thickness, score of intrauterine adhesion, hormone levels, basic body temperature, body mass index, liver and kidney function, indicators related blood clots(coagulation routine, D- dimer, homocysteine)Methods: 15 patients who had fertility requirements and diagnosed with IUA by seeing a doctor in gynecologic endocrine clinic of the second hospital, hebei medical university. There were normal ovarian function, no history of serious medical conditions, with the exception of endometrial lesions, no taboo. The general condition, history of surgery and the Menstruation situation before the TCRA were collected.The standard for evaluation of the American association of infertility(AFS) in 1988 was adopted to evaluate the degree of IUA.The TCRA was going on after Improving the preoperative examination. Sodium hyaluronate,5ml,and Foley catheter ware placed after TCRA. Antibiotics used for 7days,vaginally administered Finn 1mg/d were used for 12 weeks after TCRA.The ultrasound,hormone levels and BBT were examined during the treatment. The menstrual quantity, preopreative examination and hysteroscopy examination were needed fter the bleedingevaluation of therapeutic efficiency:The score of IUA, menstrual quantity, endometrial thickness, Serum estradiol level and BBT were used to evaluate the efficiency of the treatment. BMI, liver and kidney function, indicators related blood clots(coagulation routine, D- dimer, homocysteine) were used to evaluate the security of the treatment.All the data are processed by SPSS 13.0 software. T text was used for count data.Inspection level of alpha = 0.05.Results: The cause of IUA:Artficial abortion operation(10/15),dilatatiom and curettage(2/15),IVF-ET(2/15),induction of labour(1/15). Uterine cavity operation is the main reason of IUA.After 2 weeks,4 weeks,8 weeks,12 weeks of the treatment, the serum estradiol level was 834.47±151.01pg/ml 、 998.73±117.93 pg/ml 、1056.40±111.43 pg/ml 、 1103.67±126.04 pg/ml, average value was 998.32±63.50 pg/ml.The BBT during the treatment was single phase, ovulation wasn’t found with ultrasound.The endometrial thickness was 0.42±0.13 cm before the treatment, while after the treatment it was 0.65±0.26 cm.P=0.000(<0.05). The endometrial thickness of patients increase with vaginally administered Finn.The menstrual quantity was 10.4±2.25 ml before the treatment, while after the treatment it was 19.6±3.11 ml.P=0.000, The menstrual quantity of patients is increased with vaginally administered Finn.The score of IUA was 7.87±0.57 before the treatment, while after the treatment it was 6.13±0.60.P=0.047, The degree of IUA is eased with vaginally administered Finn.The BMI was 22.31±0.97kg/m2 before the treatment, while after the treatment it was 22.60±0.94kg/m2.P=0.155, The BMI isn’t changed with vaginally administered Finn.The liver and kidney function, indicators related blood clots were in the normal range.Conclusion: Uterine cavity operation is the main reason of IUA. The endometrial thickness and menstrual quantity of patients are increased with vaginally administered Finn. The degree of IUA is eased with vaginally administered Finn. Vaginally administered Finn is effective and safe.