Research Of Relationship Between Ischemic White Matter Lesions And Depression

Objective To investigate the incidence of depression in patients with ischemic cerebral white matter lesions; The relationship between different degrees of ischemic cerebral white matter lesions associated with depression and their correlation.Methods Patients in the Department of Neurology of the Second Hospital of Lanzhou University from September 2013 to December 2014 examined 3.0T head MRI. According to the diagnosis of WML,126 cases with WML were checked out as case group. According to the Fazakas scale,126 patients with WML were classified into 3 subgroups depending on the degree.44 cases were selected as control group in the Department of Neurology of The Second Hospital of Lanzhou University in the same period, and their head MRI examinations were normal. The general conditions (gender, age, education age, blood pressure, blood sugar, blood fat)of the control group suited to the case group.All case group and control group tested by Hamilton Depression Rating Scale (HAMD) to analysis the relationship between different degrees of WML and depression.Results 1. WML group had higher incidence of depression than the control group, the difference had statistical significanence(P<0.05).2.Compared with control group, the patients with different degrees of WML had higher Hamilton depression score. Medium and severe WML groups had higher Hamilton depression score than those of the mild WML group and the control group, the difference had statistical significanence(P<0.05,respectively).Severe WML groups had higher Hamilton depression score than that of the medium WML group, the difference had statistical significanence (P<0.05).3. The severity score of WML had significantly correlated with the Hamilton depression score (r=0.407,P< 0.05).Conclusion Ischemic cerebral white matter lesions may lead to depression; Patients with ischemic cerebral white matter lesion have a higher incidence of depression The heavier the degree of ischemic cerebral white matter lesions, the heavier the degree of depression. The severity of ischemic cerebral white matter lesion is positively correlated with the depression.