| As one of commonly used inhalation anesthetics, sevoflurane has been widely used in obstetric and pediatric anesthesia for its hemodynamic stability, short-lasting action and excellent respiratory tolerance. However, there maybe some side effects caused by sevoflurane. Increasing evidence indicates that sevoflurane exposure leads to widespread neuroapoptosis and cognitive impairment on immature brain.This has raised serious concerns among anaesthesiologists, neuroscientists and parents regarding the safety of sevoflurane on brain development. The identification of possible mechanisms is currently under investigation. This article reviews the current literature relating to the neurotoxicity of Sevoflurane,possible mechanism and prevention measures.the molecular processes of influence of sevoflurane on the developing brain should be understood to develop novel therapeutic strategies that can prevent sevoflurane-induced neurotoxicity and provide neuroprotection against developmental central nervous system. |
