Explore The Relationship Between Thrombocytosis And Rectal Cancer Metastasis

Objective:To study the changes of platelet counts in patients with rectal cancer, analyze the causes and the interaction of platelets and platelet rectal cancer patients with tumors increased, so as to explore the relationship between platelet increased and rectal cancer patients evaluation, to provide reference for clinical practice. Methods:The 100 patients with rectal cancer were randomly, selected between January 2010 to October 2013 of the Shandong province Dong Ping County People’s Hospital as the object, including 64 cases of male patients, female patients of 36 cases, the male to female ratio was 1.78:1,aged between 25-82 years old, average age 62 ± 11.932 years old. On the basis of random and concurrent control two principles, in addition to select 100 healthy people as control group, including 60 cases of male patients, female patients of 40 cases, the male to female ratio was 1.5:1, aged between 23-78 years old, average age 60.3 ± 11.9 years old. The patients in the hospital after second days(before operation) and second days after the application of 7:00 vacuum vessel in the morning fasting venous blood 2ML, health examination in the second days after admission in the morning 7:00 fasting venous blood 2ML, test the platelet count(PLT), respectively, from the following aspects: a comparative analysis rectal cancer patients with postoperative PLT count, cancer patients and healthy patients, PLT counts were compared in different pathological types of PLT in patients with rectal cancer, count of differentiated PLT in patients with rectal cancer, count of different degree of invasion of rectal cancer patients PLT count, tumor size of different PLT in patients with rectal cancer, different count classification of PLT in patients with rectal cancer, rectal cancer patients count PLT count and lymph node metastasis of rectal cancer patients compared, PLT count and analysis without intestinal obstruction, and comparative analysis of PLT in patients with rectal cancer patients’ age, gender and count. Results:1. In patients with rectal cancer PLT counts decreased. Patients with preoperative rectal PLT count was 263.40 ± 88.855(×109/L), after PLT count was 187.09 ± 60.048(×109/L), the difference was statistically significant(P <0. 05).2. PLT in patients with rectal cancer count was higher than that of healthy patients. Rectal cancer preoperative group PLT count was 263.40 ± 88.855(×109/L), health examination group PLT count was 201.5 ± 60.6(×109/L), PLT count than after group, there was significant difference(P < 0.05).3. Of different pathological types of rectal cancer compared with PLT count increased in different ratios, gland cancer patient PLT count increased ratio of 35%, adenocarcinoma and mucinous adenocarcinoma component with PLT count increased ratio of 56%, mucus gland cancer patients PLT count increased ratio was 40%, there was no significant difference(P > 0.05).4. High differentiation of PLT in patients with rectal cancer count increased ratio of 14%, in the differentiation of PLT in patients with rectal cancer count increased ratio of 31%, low differentiation of PLT in patients with rectal cancer count increased ratio of 57%, different degrees of PLT in patients with rectal cancer count increased rate compared with the degree of differentiation, the lower PLT counts were increased, the higher the incidence, there was significant difference.( P <0.05).5. The depth of tumor invasion into the mucosa of patients with PLT count increased ratio of 0%, the depth of tumor invasion into the submucosa of the patients with PLT count increased ratio of 10%, the depth of tumor invasion to muscle in patients with PLT count increased ratio of 43.5%, the depth of tumor invasion in the serosa patients outside the PLT count increased ratio of 57.7%, different the depth of invasion of rectal cancer PLT count increased rate compared with the depth of invasion, deeper, PLT count increased incidence higher, there was significant difference.(P< 0.05).6. The ratio of tumor diameter ≥5cm PLT count increased in 47% patients with rectal cancer, tumor size <5cm PLT in patients with rectal cancer count increased ratio of 23%, tumor size(length to diameter) of different PLT in patients with rectal cancer count increased rate compared with patients with PLT count, ratio of length to diameter larger tumors increased more high, there was a significant difference(P < 0.05).7. Ratio in patients with rectal cancer ulcer type PLT count increased to 38%, the ratio of PLT in patients with rectal cancer mass count increased in 35% patients with rectal cancer, infiltration ratio PLT count increased in 0% rectal cancer, gross type packet count increased rate compared with PLT, no significant difference(P >0.05).8. Lymph node ratio increased transfer positive PLT in patients with rectal cancer count is 48%, rate of lymph node metastasis negative PLT count increased in 28.6% patients with rectal cancer. Lymph node ratio increased metastatic rectal cancer patients was higher than that of group PLT count positive lymph node metastasis negative patients with rectal cancer group, there was significant difference(P <0.05).9. A ratio with symptoms of preoperative patients with rectal obstruction PLT count increased in 82%, with no symptoms of intestinal obstruction ratio of PLT in patients with rectal cancer count increased in 31.5% patients with rectal cancer. Rate of patients with rectal cancer group PLT count with symptoms of preoperative obstruction in patients with rectal cancer increased higher than the group without symptoms of intestinal obstruction, there was a significant difference(P <0.05).10. Above the age of 60 groups of patients with rectal cancer and age ≤ 60 years old patients with rectal cancer group increased compared with PLT count ratio, no significant difference(P >0.05).11. Male patients with rectal cancer and female patients with rectal cancer group PLT count increased ratio in comparison, there was no significant difference(P > 0.05). Conclusion:Rectal cancer patients with increased platelet, Increased platelet associated with the degree of tumor differentiation, depth of bowel wall invasion in rectal cancer patients, tumor size, tumor peripheral and mesenteric lymph node metastasis, intestinal obstruction exists. To observe the changes of platelet count in patients with rectal cancer dynamic, can be used as a reference marker in patients with rectal cancer assessment.