Clinical Manifestations And Pregnancy Outcomes Of Pregnant Women With Systemic Lupus Erythematosus: A Study Of 67 Cases

ObjectiveTo investigate the clinical characteristics and pregnancy outcomes of pregnant women with systemic lupus erythematosus (SLE).MethodsCollect and analyze retrospectively the clinical data of 67 pregnant women (67 cases) with SLE recruited to Qilu Hospital of Shandong University from Aug 2005 to Aug 2014. Evaluate the disease severity and activity of 67 pregnant women with SLE referencing SLE disease activity index, with cases of scores≤4 in non-flare group(31 cases) and cases of scores≥5 in flare group(36 cases). Compare and analyse the incidence rates of preterm birth, small for gestational age infant, therapeutic abortion, pregnancy loss and severe preeclampsia.ResultsThere were no statistical differences in age, gravidity and course of disease between the two groups(P>0.05).Compare with the non-flare group, the flare group’s incidence rates of live birth (50%:100%) and full-term birth (38.9%:67.7%) is lower significantly(P< 0.05 for all), while the flare group’s incidence rates of therapeutic abortion (30.6%:0%) preterm birth (61.1%:32.3%), small for gestational age infant (44.4%: 6.5%),pregnancy loss (50%:0%) and severe preeclampsia (61%:6.5%) increased significantly(P<0.05 for all). There were significant statistics differences between these data.But there were no statistics differences in the incidence rates of the mode of delivery(spontaneous vaginal delivery and cesarean section) et al.The activity of SLE was mostly occurred in the middle and late pregnancy, with the highest rate of proteinuria, skin rash, followed by the thrombocytopenia, febrile. SLE flare in early pregnancy harmed the blood system, kidney, while led to multi system damage in middle and late pregnancy.ConclusionSLE flare led to damage of the blood system, kidney and increased risks of poor fetal and maternal outcomes. Thus, for a better outcome of lupus pregnancy, it is essential to make a thoughtful plan, ensure a stable condition for at least 6 months before conception and monitor the clinical index closely during pregnancy, for early detection and timely treatment.