| Objective:The purpose of this study is to evaluate prognostic factors and survival in patients with incompletely resected NSCLC following surgical resection and to investigate whether there is survival difference in different treatments.Methods:Thirty-two incompletely resected NSCLC patients who completed scheduled PORT (Postoperative radiotherapy) for positive resection margin, among 1231 patients following surgical resection in our hospital from January 2008 to November 2014 were retrospectively analyzed. Radiation therapy was started at 4 to 6 weeks after surgery. Chemotherapy was also administered to 21 patients, either sequentially or concurrently with PORT. The postoperative pathological stages were Ⅰ(n= 6),Ⅱ(n= 10),ⅢA (n=14), and IIIB (n=2). The histology included squamous cell carcinoma (n=24), adenocarcinoma (n=5) or other types (n=3).Results:The median age of patients was 63 years (range,40 to 82 years). The 3-year overall survival, locoregional relapse-free survival and distant metastasis-free survival rates were37.6%,68.5%,61.5%. The median overall survival was 27.8 months (range,15.4 to 40.1months), an Univariate analyses showed that age<63 (P=0.002), N0-1 stage(P<0.05), stage I (P<0.05)were significant predictors for better os. T1-2 was a significant predictor for better locoregional relapse-free survival (P=0.017) and distant metastasis-free survival rates(P=0.002). Multivariate analyses showed that age <63 (P=0.004) and I stage(P=0.007) were significant predictors for better os. Chemotherapy did not influence the failure pattern or survival outcome.Conclusions:In conclusion, postoperative radiotherapy for incompletely resected NSCLC could achieve a relatively high local control rate. However, in terms of individual, different treatment strategies should be considered properly. Major failure pattern was distant metastasis despite chemotherapy. |
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